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Synergistic effect of photodynamic therapy and cisplatin: a novel approach for cervical cancer

Grant number: 12/25414-0
Support type:Scholarships in Brazil - Master
Effective date (Start): July 01, 2013
Effective date (End): February 28, 2015
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Carla Raquel Fontana Mendonça
Grantee:Laura Marise de Freitas
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The cervical cancer is a female malignant tumor that begins with intraepithelial changes of progressive nature, having HPV infection as one of the main risk factors for its emergence. The prevalence is high among young women (aged 20 to 25 years), especially in developing countries. Current therapies for the treatment of cervical cancer has been shown to be satisfactorily effective, but the biggest drawback common to all methods is the substantial excision of the cervical stroma, which can cause complications in future pregnancies. Photodynamic therapy (PDT) is proving to be a promising alternative to current treatments against many types of cancer, including cervical cancer. The technique is based on the administration of a nontoxic photosensitizing agent to the patient with subsequent exposure to a light source of predetermined wavelength. The photosensitizer (PS) selectively accumulates in tumor cells and the tissue becomes sensitive to the specific wavelength absorbed by the PS, resulting in cytotoxic response via oxidative damage. Thus, the present study aims to evaluate the efficacy of photodynamic therapy in vitro to induce cell death in cell lines infected with HPV16 (SiHa), using the photosensitizers Photogem® and methylene blue, and the association of PDT with the drug cisplatin.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE FREITAS, LAURA MARISE; SERAFIM, RODOLFO BORTOLOZO; DE SOUSA, JULIANA FERREIRA; MOREIRA, THAIS FERNANDA; DOS SANTOS, CLAUDIA TAVARES; BAVIERA, AMANDA MARTINS; VALENTE, VALERIA; SOARES, CHRISTIANE PIENNA; FONTANA, CARLA RAQUEL. Photodynamic therapy combined to cisplatin potentiates cell death responses of cervical cancer cells. BMC CANCER, v. 17, FEB 10 2017. Web of Science Citations: 4.
DE FREITAS, LAURA MARISE; SOARES, CHRISTIANE PIENNA; FONTANA, CARLA RAQUEL. Synergistic effect of photodynamic therapy and cisplatin: A novel approach for cervical cancer. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 140, p. 365-373, NOV 2014. Web of Science Citations: 14.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FREITAS, Laura Marise de. Efeito sinérgico entre a terapia fotodinâmica e a cisplatina : uma nova abordagem para o câncer de colo uterino. 2015. 73 f. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Farmacêuticas..

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