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RNA-binding proteins and post-transcriptional variations: influence on glioblastoma multiforme development

Grant number: 13/07159-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2013
Effective date (End): March 31, 2017
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Pedro Alexandre Favoretto Galante
Grantee:Bruna Renata Silva Corrêa
Home Institution: Hospital Sírio-Libanês. Sociedade Beneficente de Senhoras (SBSHSL). São Paulo , SP, Brazil
Associated scholarship(s):13/25483-4 - Identification and functional analysis of RNA binding proteins associated with the development of glioblastoma multiform, BE.EP.DR

Abstract

Glioblastoma multiforme (GBM) is one of the most aggressive tumor types, with a median survival time of 15 months. Furthermore, current treatments are not able to prevent tumor recurrence in most cases. Understanding basic aspects of tumor biology, such as its origin, development and resistance is crucial to develop more effective therapies. RNA binding proteins (RBPs) are among the molecules involved in the genesis and development of the GBM. RBPs are critical post-transcriptional gene expression regulators. They are implicated in several cellular processes, like mRNA and miRNA processing, stability, degradation, polyadenylation, translation and splice site selection. Changes in their expression levels may cause severe alterations in the cellular proteome, which will lead to diseases states and tumorigenesis. Here, we propose to investigate the influence of changes in expression of RBPs and RNA processing events in the development and resistance of GBM using isolated Glioma Stem Cells (GSCs) which will be explored with RNA-Seq, bioinformatics analysis and biological assays to access tumorigenic potential. Therefore, we expected to improve our knowledge regarding the influence of RBPs and RNA processing events in the GBM development and resistance. (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GUARDIA, GABRIELA D. A.; CORREA, BRUNA R.; ARAUJO, PATRICIA ROSA; QIAO, MEI; BURNS, SUZANNE; PENALVA, LUIZ O. F.; GALANTE, PEDRO A. F. Proneural and mesenchymal glioma stem cells display major differences in splicing and lncRNA profiles. NPJ GENOMIC MEDICINE, v. 5, n. 1 JAN 16 2020. Web of Science Citations: 0.
BETTONI, FABIANA; MASOTTI, CIBELE; CORREA, BRUNA R.; DONNARD, ELISA; DOS SANTOS, FILIPE F.; SAO JULIAO, GUILHERME P.; VAILATI, BRUNA B.; HABR-GAMA, ANGELITA; GALANTE, PEDRO A. F.; PEREZ, RODRIGO O.; CAMARGO, ANAMARIA A. The Effects of Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer-The Impact in Intratumoral Heterogeneity. FRONTIERS IN ONCOLOGY, v. 9, SEP 27 2019. Web of Science Citations: 0.
VELASCO, MITZLI X.; KOSTI, ADAM; GUARDIA, GABRIELA D. A.; SANTOS, MARCIA C.; TEGGE, ALLISON; QIAO, MEI; CORREA, BRUNA R. S.; HERNANDEZ, GRECO; KOKOVAY, ERZSEBET; GALANTE, PEDRO A. F.; PENALVA, LUIZ O. F. Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development. RNA, v. 25, n. 7, p. 768-782, JUL 2019. Web of Science Citations: 0.
CORREA, BRUNA R. S.; HU, JOANNA; PENALVA, LUIZ O. F.; SCHLEGEL, RICHARD; RIMM, DAVID L.; GALANTE, PEDRO A. F.; AGARWAL, SEEMA. Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity. SCIENTIFIC REPORTS, v. 8, MAR 6 2018. Web of Science Citations: 10.
CORREA, BRUNA R.; DE ARAUJO, PATRICIA ROSA; QIAO, MEI; BURNS, SUZANNE C.; CHEN, CHEN; SCHLEGEL, RICHARD; AGARWAL, SEEMA; GALANTE, PEDRO A. F.; PENALVA, LUIZ O. F. Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma. Genome Biology, v. 17, JUN 10 2016. Web of Science Citations: 11.
CAMBULI, F. M.; CORREA, B. R.; REZZA, A.; BURNS, S. C.; QIAO, M.; UREN, P. J.; KRESS, E.; BOUSSOUAR, A.; GALANTE, P. A. F.; PENALVA, L. O. F.; PLATEROTI, M. A Mouse Model of Targeted Musashi1 Expression in Whole Intestinal Epithelium Suggests Regulatory Roles in Cell Cycle and Stemness. Stem Cells, v. 33, n. 12, SI, p. 3621-3634, DEC 2015. Web of Science Citations: 11.

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