Thyroid hormone abnormalities in patients with micro and macrovascular complications of type 1 and 2 Diabetes Mellitus

• Grant number: 13/03295-1
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: July 01, 2013
• End date: October 20, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Denise Engelbrecht Zantut Wittmann
• Grantee: Arnaldo Moura Neto
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Thyroid hormone abnormalities known as nonthyroidal illness syndrome (NTIS) are characterized by a fall in serum triiodothyronine levels in total and free forms (TT3 and FT3) and an increase in the reverse form (rT3), concurrently with normal thyrotropin (TSH) levels. A more severe underlining disease can result in a decrease in serum thyroxine (T4). It occurs mainly in patients with acute and severe diseases, particularly in those admitted in intensive care units. The physiopathology involves diminished peripheral conversion of T4 to T3 and inactivation of T4 to rT3 resulting in lower T3 levels and increased rT3. There is no elevation in TSH, as would be expected. It has been established an important correlation between worse prognosis and lower serum T4 levels. Much has been studied about this syndrome in severe diseases, but not only in acute settings. The syndrome has been described in patients with chronic conditions under outpatient care, including Diabetes Mellitus, mostly when presenting with poor glycaemic control. However, there is a lack of studies relating the presence of its complications (nephropathy, neuropathy and retinopathy) and subclinical systemic inflammation with the severity and evolution of NTIS, as well as its thyroid hormone profile. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NETO, ARNALDO MOURA; ZANTUT-WITTMANN, DENISE ENGELBRECHT. Abnormalities of Thyroid Hormone Metabolism during Systemic Illness: The Low T3 Syndrome in Different Clinical Settings. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2016. (13/03295-1)

NETO, ARNALDO MOURA; RIBEIRO PARISI, MARIA CANDIDA; ALEGRE, SARAH MONTE; PAVIN, ELIZABETH JOAO; TAMBASCIA, MARCOS ANTONIO; ZANTUT-WITTMANN, DENISE ENGELBRECHT. Relation of thyroid hormone abnormalities with subclinical inflammatory activity in patients with type 1 and type 2 diabetes mellitus. ENDOCRINE, v. 51, n. 1, p. 63-71, JAN 2016. (10/08854-0, 13/03295-1)

NETO, ARNALDO MOURA; ZANTUT-WITTMANN, DENISE ENGELBRECHT. Abnormalities of Thyroid Hormone Metabolism during Systemic Illness: The Low T3 Syndrome in Different Clinical Settings. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, v. 2016, p. 9-pg., 2016-01-01. (13/03295-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MOURA NETO, Arnaldo. Relation of thyroid hormone abnormalities with subclinical inflammatory activity in patients with type and type 2 diabetes mellitus. 2016. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.