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Relation of thyroid hormone abnormalities with subclinical inflammatory activity in patients with type and type 2 diabetes mellitus

Full text
Author(s):
Arnaldo Moura Neto
Total Authors: 1
Document type: Doctoral Thesis
Press: Campinas, SP.
Institution: Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas
Defense date:
Examining board members:
Denise Engelbrecht Zantut Wittmann; Maria Lucia Cardillo Corrêa Giannella; Gláucia Maria Ferreira da Silva Mazeto; Elza Olga Ana Muscelli Berardi; Heraldo Mendes Garmes
Advisor: Denise Engelbrecht Zantut Wittmann
Abstract

Introduction: The non-thyroidal illness is characterized by low serum levels of triiodothyronine and, sometimes, thyroxine. It is mainly observed in patients with severe acute diseases, where it is linked to an increased inflammatory activity. Recently, it has been described in a variety of chronic ambulatory conditions, including diabetes mellitus (DM). In these cases, it is related to poor glycemic control. Objectives: Compare the clinical characteristics, thyroid hormone profile e systemic inflammatory markers between patients with type 1 and type 2 diabetes and healthy, non-diabetic individuals, paired by sex, age and body mass index (BMI). Methodology: This was a cross-sectional study involving 258 subjects divided in four groups: 70 patients with T2DM, 55 with T1DM and two control groups with 70 and 63 individuals without DM paired by age, sex and MBI with the T2DM and T1DM patients, respectively. Clinical and anthropometrical data were evaluated in all groups, as well as serum thyroid hormones TSH, reverse T3, C-reactive protein, interleukin-6 (IL-6) and serum amyloid protein (SAA) as markers of inflammation. The relations free T4/ free T3, free T3/ reverse T3 and free T4/ reverse T3 were used as surrogate markers of deiodinase activities. Results: Total and free T3 were lower in patients with T1DM and T2DM compared to their respective control groups (p<0.001 for all)...Note: The complete abstract is available with the full electronic document (AU)

FAPESP's process: 13/03295-1 - Thyroid hormone abnormalities in patients with micro and macrovascular complications of type 1 and 2 Diabetes Mellitus
Grantee:Arnaldo Moura Neto
Support Opportunities: Scholarships in Brazil - Doctorate