Interaction with mesenchymal stem cell and breast cancer lineage cells and evaluation of biological behavior

• Grant number: 13/04659-7
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): July 01, 2013
• Effective date (End): May 31, 2018
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Daniel Guimarães Tiezzi
• Grantee: Fernanda Marques Rey
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 16/02730-4 - Tumorigenic reversion properties using 5-aza-dC and TSA on DNA methylation and breast cancer progression, BE.EP.DR

Abstract

Breast cancer is a disease highly prevalent and incident. Recently has been cited in the literature that the integration between tumor stroma and epithelial cells malignant is an important factor in resistance to cytotoxic treatment. Studies show that Mesenchymal stromal cells tumor originating form a favorable microenvironment for the maintenance of stem cell tumor (CTTS) responsible for the recurrence distance. This sub-population of CTTS is able to repopulate the tumor cells with host same origin. It is postulated that this interaction translates into the ability of tumor invasion and metastatic potential. This study aims to examine the association of cells tumor lineage MCF-7 human mesenchymal stem cell, to study changes in phenotypic and biological behavior. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

REY, Fernanda Marques. Interaction of mesenchymal stem cell with breast cancer lineage cells and evaluation of their biological behavior. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.