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PROTEIC EXPRESSION STUDY IN PLASM AND URINE IN RENAL TRANSPLANT RECIPIENTS RECEIVING DIFFERENT IMMUNOSUPPRESSIVE REGIMENS

Grant number: 13/06310-1
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2013
Effective date (End): August 31, 2016
Field of knowledge:Health Sciences - Medicine
Principal researcher:Dulce Elena Casarini
Grantee:Claudia Rosso Felipe Bonato
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Kidney transplantation is a therapeutic option for patients with ESRD. Advances in surgical techniques and especially the development and approval of new immunosuppressive drugs in recent years have contributed significantly to improvements in survival and graft transplant patient. Among the many available immunosuppressive regimens for prophylaxis of acute rejection after renal transplantation, currently the most widely used regimen consists of tacrolimus, mycophenolate, and prednisone. Compared to the schemes previously used, this combination showed better efficacy, with significant reduction in the incidence of acute rejection. However, its safety profile is affected by significant adversities that often lead to disruption or termination of the scheme. Among the main problems of security of this scheme we highlight the adverse events and gastrointestinal cytomegalovirus infection.An immunosuppressive regimen that maintains low rates of acute rejection, and to reduce the incidence and severity of CMV infections and gastrointestinal events, could therefore lead to superior results.The objectives of this exploratory project are:1. Evaluate the proteomic profile in acute transplant rejection in patients receiving renal transplantation with or without CMV viral load.2. To evaluate the proteomic profile CMV infection in patients in renal transplant recipients, and the effect of CMV infection on mTOR signaling pathway in patients with different immunosuppressive regimens, with and without inhibitors of mTOR

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