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Analysis of the indoleamine 2,3 - dioxygenase (IDO) expression in renal tissue during the epithelial-mesenchymal transition process induced in the model of ureteral unilateral obstruction (UUO)

Grant number: 13/07183-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2013
Effective date (End): June 30, 2015
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Humberto Dellê
Grantee:Gislene Mendes Simão
Home Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil

Abstract

One of the most important processes leading to loss of renal function is the fibrogenesis, which is characterized by extracellular matrix deposition leading to glomerulosclerosis and tubulointerstitial fibrosis. One of the pathways responsible for fibrogenesis is the epithelial-mesenchymal transition (EMT), where the tubular cells acquire mesenchymal phenotype increasing the number of myofibroblasts, cells responsible for depositing extracellular matrix leading to fibrosis. The enzyme IDO is recognized as immunomodulatory molecule, especially to be present in placenta, ensuring the survival of embryonic tissue against the maternal immune system. Once IDO expression is detected in renal tubules, there is great interest in studying this enzyme in kidney transplantation. In addition, recent studies have demonstrated an increased renal expression of IDO in models of renal ischemia and chronic renal disease, suggesting a possible role of the enzyme in the pathophysiology of renal diseases. In this context, this study aims to analyze the expression of IDO in an animal model of UUO (unilateral ureteral obstruction), a classical model of tubulointerstitial fibrosis, in order to relate the IDO expression with the process of EMT and fibrosis. Because the EMT is induced by TGF-beta 1 and this factor induces IDO, it is possible that this pathway plays a role in the pathophysiology of tubulointerstitial fibrosis. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOMES MATHEUS, LUIZ HENRIQUE; SIMAO, GISLENE MENDES; AMARAL, TAISSA ALTIERI; OLIVEIRA BRITO, RODRIGO BARBOSA; MALTA, CAMILA SOARES; TELES MATOS, YVES SILVA; SANTANA, ALEXANDRE CHAGAS; CARDOSO RODRIGUES, GABRIELA GOMES; ALBEJANTE, MARIA CLARA; BACH, ERNA ELISABETH; DALBONI, MARIA APARECIDA; CAMACHO, CLEBER PINTO; DELLE, HUMBERTO. Indoleamine 2, 3-dioxygenase (IDO) increases during renal fibrogenesis and its inhibition potentiates TGF-beta 1-induced epithelial to mesenchymal transition. BMC Nephrology, v. 18, SEP 6 2017. Web of Science Citations: 1.

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