Scholarship 13/07913-1 - Serotonina, Ratas - BV FAPESP
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Does hormonal therapy prevent behavioral and neural alterations involved to anxiety-like behavior in perimenopausal female rats?

Grant number: 13/07913-1
Support Opportunities:Scholarships in Brazil - Doctorate
Start date until: September 01, 2013
End date until: December 31, 2016
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Janete Aparecida Anselmo Franci
Grantee:Paulo de Tarso Silva Barros
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The perimenopause, transition between reproductive age and menopause, is the time in which main endocrine and clinical alterations have led to disturbances in women during this phase. Progressive decrease of ovarian follicles is involved to an erratic pattern of hormone levels, e.g. slight increase of the plasma follicle stimulating hormone, from normal to increased estradiol and decreased progesterone levels. In addition to endocrine disturbances, clinical alterations have emerged, like hot flushes, night sweats, fatigue, headache and mood disorders, mainly depression and anxiety.It has been demonstrated that VCD (4-vinylcyclohexene diepoxide) perimenopause model in rodents exhibit same alterations similar to those observed in perimenopausal women, e.g. progressive decrease of ovarian reserve of follicles, which lead to ovarian failure. In addition, previous data of our lab have shown that VCD-treated rats present anxiety-like behaviors. However, the hormonal pattern remains unclear.Therefore, the goal of this project is to study the hormonal pattern of rats in perimenopause. In addition to the hormone secretion, it is also our goal to investigate if there are changes in the serotonergic system and if hormonal therapy with estradiol and/or progesterone is capable of prevent the behavioral and neural disturbances involved to anxiety-like behavior in rats during perimenopause induced by VCD.

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