|Support type:||Scholarships in Brazil - Scientific Initiation|
|Effective date (Start):||September 01, 2013|
|Effective date (End):||December 31, 2014|
|Field of knowledge:||Physical Sciences and Mathematics - Chemistry - Physical-Chemistry|
|Principal Investigator:||Ana Paula Ramos|
|Grantee:||Camila Bussola Tovani|
|Home Institution:||Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil|
Tube-like structures have attracted scientists attention due to their peculiar features tailored by geometry and composition that combined can origins materials with high surface area and high mechanic strength. These materials can be applied in several fields like microelectronics and biomedicine. For the last, it is recommended to get information about the toxicity, biocompatibility and bioactivity of the materials. In this sense, materials formed by calcium carbonates and phosphates those are minerals abundant in natural systems and biocompatibles, can be used for biomedical applications.The aim of the present project is the preparation and characterization of CaCO3 nanotubes. The bioactivity of this material will be tested in colloidal dispersions as well as in films deposited on titanium surfaces using a layer-by-layer (LbL) polyelectrolyte matrix. The LbL films will be formed using biopolymers like oppositely charged polysaccharides. In the first stage, the CaCO3 nanotubes will be grow in a simple way by using porous polycarbonate membranes as templates. The characterization of the composition of the samples will be carried out by using Fourier transform infrared spectroscopy (FTIR). The morphology will be studied by using scanning electron microscopy (SEM) and transmission electron microscopy. The crystallinity will be investigated by x-ray diffraction. After the deposition of the LbL films, the titanium surface will be characterized with relation to its composition, morphology, topography and surface energy by FTIR, SEM, atomic force microscopy and contact angle measures, respectively. To the bioactivity evaluation, the nanotubes dispersion as well as the modified surfaces will be exposed to a solution that simulates the ionic composition of the human plasma. It is expected at the end of the project, the comprehension of the parameters that affect the formation of the nanotubes and hybrid films, and how its influence in the bioactivity of the titanium surfaces.