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EcPVs DNA detection in aural plaques samples before and after imiquimod treatment

Grant number: 13/13973-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2013
Effective date (End): July 31, 2014
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal researcher:José Paes de Oliveira Filho
Grantee:Luiza Stachewski Zakia
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


The aural plaque is a cosmopolitan disease in distribution that causes discomfort to the animals and economical losses to the owners. Seven types of Equus caballus papillomavirus (EcPV) have been identified. Four of them were associated with aural plaque, EcPV3, 4, 5 e 6. Even though the lesions do not regress spontaneously, a previous study demonstrated success on treating aural plaques with imiquimod cream 5%. However, this study was performed previously the association of the EcPVs with aural plaque in horses; for that reason, any studies that detect the presence of de viral DNA after treatment have been done yet. Therefore, the aim of this study is to verify the presence of the EcPV1-7 DNA by PCR in samples of aural plaques before and after the treatment of the lesions with imiquimod, as well as to evaluate the treatment efficiency clinically.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ZAKIA, LUIZA S.; OLIVO, GIOVANE; BASSO, ROBERTA M.; MIRA, JULIANA; HERMAN, MARIANA; ARAUJO, JR., JOAO P.; BORGES, ALEXANDRE S.; OLIVEIRA-FILHO, JOSE P. Imiquimod treatment for Equus caballus papillomavirus infection in equine aural plaques. VETERINARY DERMATOLOGY, v. 27, n. 3, p. 175+, JUN 2016. Web of Science Citations: 3.
ZAKIA, L. S.; BASSO, R. M.; OLIVO, G.; HERMAN, M.; ARAUJO, JR., J. P.; BORGES, A. S.; OLIVEIRA-FILHO, J. P. Detection of papillomavirus DNA in formalin-fixed paraffin-embedded equine aural plaque samples. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 67, n. 4, p. 1193-1196, AUG 2015. Web of Science Citations: 2.

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