| Grant number: | 13/11721-0 |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| Start date: | January 02, 2014 |
| End date: | January 01, 2015 |
| Field of knowledge: | Biological Sciences - Genetics - Human and Medical Genetics |
| Principal Investigator: | Roger Chammas |
| Grantee: | Priscila Daniele Ramos Cirilo |
| Supervisor: | Luiz Otavio Ferraz Penalva |
| Host Institution: | Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
| Institution abroad: | University of Texas Health Science Center at Houston (UTHealth), United States |
| Associated to the scholarship: | 11/18337-6 - Functional characterization of 3'UTR region of PHB gene in human melanomas, BP.PD |
Abstract Cutaneous melanoma is one epithelial tumor originates in melanocytes. This tumor represents 4% of malignant neoplasms of skin and it is considered an important public health problem because of its high progression to metastasis and treatment resistance. Previous studies of our group revealed the accumulation of prohibitin (PHB) in cell lines of human melanoma after treatment with cisplatin. PHB is an evolutionarily conserved chaperone involved in various cellular processes, including proliferation and cell cycle. Our group also showed that rare alleles of SNP rs6917 at 3'UTR of PHB gene (3'UTR-PHB) is a risk factor for the development of melanoma in patients living in regions with high UVB index. Transcripts with long 3'UTR are putative targets of post-transcriptional regulation, such as a PHB isoform. RNA binding proteins (RBPs) and microRNAs (miRNAs) are key mediators of post-transcriptional regulation and aberrant action of these factors can lead to tumorigenesis. However, post-transcriptional regulation of PHB in melanoma has not been described. In this project, will be the characterized RBPs and miRNAs that regulates the 3'UTR-PHB non-melanoma, parental and human melanoma cell line transformed with the 3'UTR-C (wild type allele) and 3'UTR-PHB-T (rare allele). After functional characterization, the post-transcriptional regulators of PHB, could be useful as putative targets of melanoma development and/or chemoresistance. (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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