Application of biotechnological tools in Streptomyces olindensis to obtain new natural products with pharmaceutical potential

• Grant number: 13/10933-4
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2013
• End date: July 31, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Mônica Tallarico Pupo
• Grantee: Raphael Conti
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery, AP.CEPID

Abstract

Deoxysugars are often seen as structural components in natural products. Important antibiotic, antifungal, antiparasitic and antitumor possessing these sugars linked to the aglycone moiety of the molecule. Typically these sugars are involved in the recognition of the active site and, therefore, their presence on the structures of natural products is in most cases connected with biological activity. Microorganisms of the genus Streptomyces exhibit a remarkable ability to produce secondary metabolites glycosylated, example, the cosmomycin D produced by Streptomyces olindensis. The cosmomycin D is a compound very promising due to its antitumor activity. Based on these data, their work will use various tools such as molecular biology, biotransformation and elicitation in an attempt to get new glycosylated bioactive compounds.Key words: Streptomyces olindensis, secondary metabolites; cosmomycin D; bioactivity; biotransformation; elicitation.