DRUG RELEASE STUDY IN TI-7.5Mo SURFACE AFTER TiO2 NANOTUBES GROWTH

• Grant number: 13/08200-9
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: September 01, 2013
• End date: December 31, 2016
• Field of knowledge: Engineering - Materials and Metallurgical Engineering
• Principal Investigator: Ana Paula Rosifini Alves
• Grantee: Ana Lúcia Do Amaral Escada
• Host Institution: Faculdade de Engenharia (FEG). Universidade Estadual Paulista (UNESP). Campus de Guaratinguetá. Guaratinguetá , SP, Brazil

Abstract

In the last years several researches have been realized for to increase cell growth in biomaterials by using nanotubes. The purpose of this project is to associate the methodology developed for nanotubes with drugs release in the Ti-7.5Mo experimental alloy. Thus will be possible to associate bone growth with minimization of the infectious process. Drugs will be incorporated and samples will be coated with polymer PLGA poly (lactic-co-glycolic acid) for drug release. Characterization techniques such as SEM - FEG, X-rays, spectroscopy UV and contact angle will be used for samples analyses. After incorporation will be realized in vitro studies, with biofilms growth and cellular viability.

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DO AMARAL ESCADA, ANA LUCIA; AFONSO CAMARGO, SAMIRA ESTEVES; REIS DE VASCONCELLOS, LUANA MAROTTA; MOREIRA MILHAN, NOALA VICENSOTO; ROSIFINI ALVES CLARO, ANA PAULA. Cytotoxicity Analysis of Ti-7.5Mo Alloy After Biomimetic Surface Treatment to Use as Dental Materials. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 20, n. 6, p. 1614-1621, NOV-DEC 2017. (13/08200-9)

DO AMARAL ESCADA, ANA LUCIA; BARROS MACHADO, JOAO PAULO; ROSIFINI ALVES CLARO, ANA PAULA. Characterization of Calcium Phosphate Coating Produced by Biomimetic Method. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 18, n. 1, p. 3-8, JAN-FEB 2015. (13/08200-9)

ROSIFINI ALVES CLAR, ANA PAULA; KONATU, REGINALDO T.; DO AMARAL ESCADA, ANA LUCIA; DE SOUZA NUNES, MIRIAM CELI; MAURER-MORELLI, CLAUDIA VIANNA; DIAS-NETIPANYJ, MARCELA FERREIRA; POPAT, KETUL C.; MANTOVANI, DIEGO. Incorporation of silver nanoparticles on Ti7.5Mo alloy surface containing TiO2 nanotubes arrays for promoting antibacterial coating - In vitro and in vivo study. Applied Surface Science, v. 455, p. 780-788, OCT 15 2018. (13/08200-9, 14/15640-8)

CHAVES, J. M.; ESCADA, A. L. A.; RODRIGUES, A. D.; ALVES CLARO, A. P. R.. Characterization of the structure, thermal stability and wettability of the TiO2 nanotubes growth on the Ti-7.5Mo alloy surface. Applied Surface Science, v. 370, p. 76-82, MAY 1 2016. (13/08200-9)

DO AMARAL ESCADA, ANA LUCIA; BARROS MACHADO, JOAO PAULO; ROSIFINI ALVES CLARO, ANA PAULA. Characterization of Calcium Phosphate Coating Produced by Biomimetic Method. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 18, n. 1, p. 6-pg., 2015-01-01. (13/08200-9)

DO AMARAL ESCADA, ANA LUCIA; AFONSO CAMARGO, SAMIRA ESTEVES; REIS DE VASCONCELLOS, LUANA MAROTTA; MOREIRA MILHAN, NOALA VICENSOTO; ROSIFINI ALVES CLARO, ANA PAULA. Cytotoxicity Analysis of Ti-7.5Mo Alloy After Biomimetic Surface Treatment to Use as Dental Materials. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 20, n. 6, p. 8-pg., 2017-11-01. (13/08200-9)