Synthesis of biodegradable/biocompatible block copolymers for obtaining polymeric micro-and nanoparticles for controlled drug release

• Grant number: 13/03355-4
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: September 01, 2013
• End date: September 30, 2018
• Field of knowledge: Engineering - Chemical Engineering
• Principal Investigator: Amilton Martins dos Santos
• Grantee: Rodolfo Minto de Moraes
• Host Institution: Escola de Engenharia de Lorena (EEL). Universidade de São Paulo (USP). Lorena , SP, Brazil

Abstract

Taking into account the growing interest in the association stimuli responsive and biocompatibility of some polymers with the biodegrability of others, to the development of controlled drug release systems, this project aims the elaboration of block copolymers constituted of poly (3-hydroxybutyrate-co-3-hydroxyvalerate)-b-poly (N-vinylcaprolactam) (PHBHV-b-PNVCL) and poly (µ-caprolactone)-b-poly (N-vinylcaprolactam) (PCL-b-PNVCL ), in which one is biodegradable (PHBHV e PCL) and the other is biocompatible and a temperature responsive (PNVCL). Those copolymers are synthesized, firstly, by esterification reactions between hydroxil termination from PHBHV and PCL blocks with the carboxil termination from NVCL homopolymers. After this, the RAFT mechanism of controlled polymerization Will be tested. To achieve this, chain transfer agent will be synthesized and used to functionalize PHBHV and PCL blocks and produce a second block of PNVCL. Finally, cicloadition 1,3 dipolar reactions between azides and alkynes ("Click Chemistry") will be studied as third technique for obtention of block copolymers. The copolymers will be used to prepare nanoparticles, containing an active principle (Paclitaxel) through emusion-diffusion/solvent evaporation tecnic. The citotoxicity of block copolymer and the active agent in vitro release will be evaluated. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MORAES, RODOLFO M.; CARVALHO, LAYDE T.; ALVES, GIZELDA M.; MEDEIROS, SIMONE F.; BOURGEAT-LAMI, ELODIE; SANTOS, AMILTON M.. Synthesis and Self-Assembly of Poly(N-Vinylcaprolactam)-b-Poly(epsilon-Caprolactone) Block Copolymers via the Combination of RAFT/MADIX and Ring-Opening Polymerizations. POLYMERS, v. 12, n. 6, JUN 2020. (13/03355-4)

DE MORAES, RODOLFO M.; DE CARVALHO, LAYDE T.; TEIXEIRA, ANA JULIA R. M.; MEDEIROS, SIMONE F.; DOS SANTOS, AMILTON M.. Well-defined amphiphilic poly(ε-caprolactone)-b-poly(N-isopropylacrylamide) and thermosensitive micelles formulation. IRANIAN POLYMER JOURNAL, v. N/A, p. 15-pg., 2023-10-04. (13/03355-4)

DE MORAES, RODOLFO MINTO; DE CARVALHO, LAYDE TEIXEIRA; ALVES, GIZELDA MARIA; MEDEIROS, SIMONE DE FATIMA; DOS SANTOS, AMILTON MARTINS. Synthesis and self-assembly of a novel block copolymer poly(N-vinylcaprolactam)-b-poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PNVCL-b-PHBHV) by the combination of RAFT/MADIX and click chemistry techniques. POLYMER BULLETIN, v. N/A, p. 28-pg., 2025-07-10. (13/03355-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MORAES, Rodolfo Minto de. Synthesis of amphiphilic and thermosensitive block copolymers, and preparation of polymeric mincro/nanoparticles for controlled drug delivery. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Escola de Engenharia de Lorena (EEL/ASDI) Lorena.