| Grant number: | 13/14203-0 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | October 01, 2013 |
| End date: | July 31, 2015 |
| Field of knowledge: | Biological Sciences - Biochemistry - Metabolism and Bioenergetics |
| Principal Investigator: | Alicia Juliana Kowaltowski |
| Grantee: | Marcel André Vieira Lara |
| Host Institution: | Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract The brown adipose tissue (BAT) is known for its thermogenic activity dependent on the expression of UCPs, uncoupling proteins located in the inner mitochondrial membrane, capable of generating heat. Recent studies demonstrate that BAT is found in humans and suggest it may be a target to treat metabolic diseases such as obesity. Mitochondrial ionic transport is of great importance to maintain cellular processes. However, the knowledge regarding ionic transport in BAT mitochondria is still limited mostly to studies involving H+ transport. It is known that BAT mitochondria are permeable to K+ ions, but the nature of the systems responsible for this transport remains unclear. On the other hand, in other tissues, ATP-sensitive K+ channels (mitoKATP) were characterized as key volume, coupling and redox state regulators. Thus, the purposes of this study are verify if BAT presents potassium channel activity as well as understand how this possible activity is capable of influencing tissue bioenergetics. | |
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