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Mitochondrial ionic transport in brown adipose tissue

Grant number: 13/14203-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2013
Effective date (End): July 31, 2015
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Alicia Juliana Kowaltowski
Grantee:Marcel André Vieira Lara
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The brown adipose tissue (BAT) is known for its thermogenic activity dependent on the expression of UCPs, uncoupling proteins located in the inner mitochondrial membrane, capable of generating heat. Recent studies demonstrate that BAT is found in humans and suggest it may be a target to treat metabolic diseases such as obesity. Mitochondrial ionic transport is of great importance to maintain cellular processes. However, the knowledge regarding ionic transport in BAT mitochondria is still limited mostly to studies involving H+ transport. It is known that BAT mitochondria are permeable to K+ ions, but the nature of the systems responsible for this transport remains unclear. On the other hand, in other tissues, ATP-sensitive K+ channels (mitoKATP) were characterized as key volume, coupling and redox state regulators. Thus, the purposes of this study are verify if BAT presents potassium channel activity as well as understand how this possible activity is capable of influencing tissue bioenergetics.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MAGDALON, JULIANA; CHIMIN, PATRICIA; BELCHIOR, THIAGO; NEVES, RODRIGO X.; VIEIRA-LARA, MARCEL A.; ANDRADE, MAYNARA L.; FARIAS, TALITA S.; BOLSONI-LOPES, ANDRESSA; PASCHOAL, VIVIAN A.; YAMASHITA, ALEX S.; KOWALTOWSKI, ALICIA J.; FESTUCCIA, WILLIAM T. Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1861, n. 5, p. 430-438, MAY 2016. Web of Science Citations: 14.
CHAUSSE, BRUNO; VIEIRA-LARA, MARCEL A.; SANCHEZ, ANGELICA B.; MEDEIROS, MARISA H. G.; KOWALTOWSKI, ALICIA J. Intermittent Fasting Results in Tissue-Specific Changes in Bioenergetics and Redox State. PLoS One, v. 10, n. 3 MAR 6 2015. Web of Science Citations: 17.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.