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Effect of Candida albicans infection on experimental Autoimmune Encephalitis Development

Grant number: 13/14353-2
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): October 01, 2013
Effective date (End): February 29, 2016
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal researcher:Alexandrina Sartori
Grantee:Thais Fernanda de Campos Fraga da Silva
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Multiple Sclerosis (MS) is a severe autoimmune disease that affects the Central Nervous System (CNS). Environmental factors such as infectious agents could trigger or exacerbate this disease. In this context, the objective of this study is to evaluate the effect of Candida albicans in the development of Experimental Autoimmune Encephalitis (EAE) that is a murine model used to study this disease. C57BL/6 mice will be infected with C. albicans before EAE induction, during the acute phase and also during the chronic EAE phase. The effect of fungal infection will be evaluated by clinical parameters (weight and score) and histopathological analysis of the CNS (presence of inflammatory infiltrates and fungi). The presumed deleterious effect will be evaluated by inoculation of C. albicans antigens (soluble and particulate) and gliotoxin. Cytokine production by spleen cells, immunophenotyping of T-cell subpopulations in the brain, determination of apoptotic cells and expression of IL-17 in the CNS will be evaluated to determine the immunopathogenic mechanism of C. albicans effect on EAE. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CAMPOS FRAGA-SILVA, THAIS FERNANDA; NISHIYAMA MIMURA, LUIZA AYUMI; TOLEDO LEITE, LAYSLA DE CAMPOS; BORIM, PATRICIA APARECIDA; WATANABE ISHIKAWA, LARISSA LUMI; VENTURINI, JAMES; PARREIRA DE ARRUDA, MARIA SUELI; SARTORI, ALEXANDRINA. Gliotoxin Aggravates Experimental Autoimmune Encephalomyelitis by Triggering Neuroinflammation. TOXINS, v. 11, n. 8 AUG 2019. Web of Science Citations: 0.
FRAGA-SILVA, THAIS F. C.; MIMURA, LUIZA A. N.; MARCHETTI, CAMILA M.; CHIUSO-MINICUCCI, FERNANDA; FRANCA, THAIS G. D.; ZORZELLA-PEZAVENTO, SOFIA F. G.; VENTURINI, JAMES; ARRUDA, MARIA S. P.; SARTORI, ALEXANDRINA. Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2015. Web of Science Citations: 7.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.