Relationship between visceral, hepatic and bone adiposity with bone mineral density and fracture occurrence in type 1 diabetes mellitus.

• Grant number: 13/09853-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: October 01, 2013
• End date: February 28, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Francisco José Albuquerque de Paula
• Grantee: Adriana Lelis Carvalho
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 14/14505-0 - Effect of energy balance on bone mass and marrow fat in type 1 diabetes mellitus, BE.EP.DR

Abstract

Bone has long been thought of purely in its structural context. Likewise, adipose tissue had been considered a metabolically inert tissue without influence on body energy utilization. Currently, evidences have revealed an important interactive role between bone and adipose tissue in the regulation of energy and mineral metabolism. Consequently, a great interest emerged in the investigation about the metabolic network involving bone and adipose tissue and on the association between diabetes mellitus (DM) and osteoporosis. The interplay between adipose tissue and bone occurs, in part, by leptin action. This adipokine secreted by adipose tissue has central and peripheral action on osteoblasts, inhibiting or stimulating bone formation, respectively. Additionally, osteocalcin, a peptide synthesized by osteoblasts, is able to stimulate both, insulin sensitivity and insulin secretion. In parallel, recent studies had demonstrated that insulin acts on osteoblasts, through binding to its receptors on the surface of osteoblasts cells, promoting bone formation. Another important aspect is that osteoblasts and bone marrow adipocytes share a common mesenchymal cell progenitor. Accordingly, the aim of this study is to assess quality and quantity of bone mass and relationship between bone and energy metabolism in patients with type 1 DM (DM1), DM1 patients underwent hematopoietic stem cells transplantation and non-diabetic subjects.Keywords: Diabetes mellitus. Osteoporosis. Osteocalcin. Bone marrow adiposity.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE PAULA, FRANCISCO J. A.; DE ARAUJO, IANA M.; CARVALHO, ADRIANA L.; ELIAS, JR., JORGE; SALMON, CARLOS E. G.; NOGUEIRA-BARBOSA, MARCELLO H.. The Relationship of Fat Distribution and Insulin Resistance with Lumbar Spine Bone Mass in Women. PLoS One, v. 10, n. 6, JUN 11 2015. (12/09527-9, 12/14603-6, 13/09853-6)

MOTYL, KATHERINE J.; GUNTUR, ANYONYA R.; CARVALHO, ADRIANA LELIS; ROSEN, CLIFFORD J.. Energy Metabolism of Bone. TOXICOLOGIC PATHOLOGY, v. 45, n. 7, p. 887-893, OCT 2017. (14/14505-0, 13/09853-6)

CARVALHO, ADRIANA LELIS; DEMAMBRO, VICTORIA E.; GUNTUR, ANYONYA R.; LE, PHUONG; NAGANO, KENICHI; BARON, ROLAND; ALBUQUERQUE DE PAULA, FRANCISCO JOSE; MOTYL, KATHERINE J.. High fat diet attenuates hyperglycemia, body composition changes, and bone loss in male streptozotocin-induced type 1 diabetic mice. Journal of Cellular Physiology, v. 233, n. 2, p. 1585-1600, FEB 2018. (14/14505-0, 14/15864-3, 13/09853-6)

CARVALHO, ADRIANA L.; MASSARO, BIANCA; E SILVA, LUCIANA T. P.; SALMON, CARLOS E. G.; FUKADA, SANDRA Y.; NOGUEIRA-BARBOSA, MARCELLO H.; ELIAS, JR., JORGE; FREITAS, MARIA C. F.; COURI, CARLOS E. B.; OLIVEIRA, MARIA C.; et al. Emerging Aspects of the Body Composition, Bone Marrow Adipose Tissue and Skeletal Phenotypes in Type 1 Diabetes Mellitus. JOURNAL OF CLINICAL DENSITOMETRY, v. 22, n. 3, p. 420-428, JUL-SEP 2019. (15/09034-0, 14/14505-0, 14/15864-3, 13/09853-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CARVALHO, Adriana Lelis. Relationship between body adiposity, marrow adipose tissue and bone mass in human type 1 Diabetes Mellitus. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.