Association between high risk HPV infection and expression of proteins reported to esophageal carcionogenesis

• Grant number: 13/15968-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: November 01, 2013
• End date: June 30, 2015
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Adhemar Longatto Filho
• Grantee: Paula Roberta Aguiar Pastrez
• Host Institution: Hospital do Câncer de Barretos. Fundação Pio XII (FP). Barretos , SP, Brazil

Abstract

Human Papillomavirus (HPV) is a small DNA virus with tropism for the squamous epithelium where it can cause hyperproliferative lesions. They are considered one of the most commom sexually transmitted infections worldwide and, according to their potential for oncogenesis based on persistent infection are classified into low- (6 and 11) or high-risk (16, 18, 31 and 33) groups. Persistent infection caused by high-risk HPV is strongly linked with the development of genital cancers and it is well established that this virus is essential for the development of carcinogenesis ano-genital and head and neck. Furthermore, evidences linking HPV to EC is increasing strenght, and the number of studies on this subject is increasing constantly, but so far no firm evidence on their role in EC carcinogeneis has been provided from Brazil and different prevalence rates from different geographic regions suggest further investigation in this field. Esophageal cancer (EC) is the 8th most incident and the 6th most fatal in the world. Brazil is considered a high-risk country for the development of EC and this disease is classified among ten most incident. The major risk factors in the development of EC include alcohol consumption, tobacco smoking, nutritional deficiency, ingestion of hard foods and/or hot liquids and infectious agents such as HPV.In the early 1980s, preliminary reports suggesting that HPV might be involved in the development of lesions of esophagus were had based on the observations of morphological similarities between HPV lesions in the genital tract and carcinomas of the esophageal mucosa. In this way, this current study aims to determine the frequence of HPV in esophageal squamous cell cancer and identify molecules involved in HPV infection and related to carcinogenesis in esophagus through immunohistochemistry. This will improve the treatment of patients and increase the survival besides this information gives us the impact of HPV vaccination on the incidence of this malignancy.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AGUIAR PASTREZ, PAULA ROBERTA; MARIANO, VANIA SAMMARTINO; DA COSTA, ALLINI MAFRA; SILVA, ESTELA MARIA; SCAPULATEMPO-NETO, CRISTOVAM; GUIMARAES, DENISE PEIXOTO; FAVA, GILBERTO; ZEMI NETO, SAID ABDALA; NUNES, EMILY MONTOSA; SICHERO, LAURA; et al. The Relation of HPV Infection and Expression of p53 and p16 Proteins in Esophageal Squamous Cells Carcinoma. JOURNAL OF CANCER, v. 8, n. 6, p. 1062-1070, 2017. (13/15968-0, 08/57889-1)