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Biodegradable synthetic nanofibers as support for stem cells in nervous system tissue regeneration

Grant number: 13/16533-8
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2013
Effective date (End): March 31, 2016
Field of knowledge:Biological Sciences - Morphology
Principal Investigator:Marimélia Aparecida Porcionatto
Grantee:Laura Nicoleti Zamproni
Home Institution: Instituto Nacional de Farmacologia (INFAR). Universidade Federal de São Paulo (UNIFESP). São Paulo , SP, Brazil
Associated scholarship(s):14/23797-4 - VEGF- and CXCL12-LOADED injectable hydrogel for mesenchymal stem cell delivery in a traumatic brain injury model, BE.EP.DR

Abstract

Injuries to the central nervous system are often highly incapacitating with few therapeutic possibilities. The use of cellular therapy with stem cell transplantation appears promising, but this process is not totally efficient because only a few cells reach the injured site and survive in the microenvironment of the lesion, which is not favorable to cell survival due to the presence of neurotoxic molecules secreted locally. To improve the regeneration of nervous tissue it is necessary to develop strategies for keeping stem cells at the injury site where they may exert their paracrine, neuroprotective and repair functions. An alternative is the use of biomaterials. Synthetic biodegradable nanofibers are filamentary structures that mimic the fibrous extracellular matrix and can function as cellular scaffolds for stem cell transplantation, functining as a support for adhesion, replication and differentiation of these cells. The objective of this study is to evaluate the effectiveness of the use of nanofibers as a scaffold for stem cell growth and to evaluate its efficacy in vivo for cell therapy for central nervous system injuries.

Matéria(s) publicada(s) na Agência FAPESP sobre a bolsa:
Stem cells help repair brain injury due to stroke 
Articles published in other midia outlets: (1 total)
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