Candida species are opportunistic pathogens isolated from human biota in the gastrointestinal tract, oral and vaginal mucosa, which can lead to the development of superficial lesions to disseminated infection, especially in cases of immunosuppression. The high toxicity, high cost of treatment and the emergence of resistant strains justify the search for new therapeutic agents. The plant biodiversity is rich in active ingredients that have contributed to the development of new and effective drugs, treatments more economical and easily accessible population. In this sense, the aim of this study is to evaluate the antifungal potential, in vitro, of ethanol extract and essential oil from leaves of Cymbopogon nardus (L.) Rendle (lemongrass) against clinical isolates of Candida spp. It will be considered the species: Candida albicans, Candida tropicalis, Candida glabrata, Candida krusei, Candida parapsilosis and Candida orthopsilosis. The essential oils present in plants of the genus Cymbopogon have been widely studied, but there are few studies involving ethanol extract of Cymbopogon nardus, including the absence of chemical analysis for this extract and no studies involving clinical isolates. The aim of this study is to evaluate the antifungal potential front isolated clinical through microdilution and kill curve analysis, cell viability and interference in biofilms, beside performance of chemical analysis of the ethanol extract and essential oil. Preliminary results from a pilot project performed in our laboratory, such as screening, showed that the essential oil of Cymbopogon nardus has significant antifungal activity against Candida species, including resistant isolates to conventional drugs, such as C. krusei and C. glabrata, which becomes this promising research for the treatment and prevention of candidiasis.
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