Acute Hepatic Failure and Liver Transplantation: Analysis of Patients Profile and Prognostic Factors at Child Institute of Clinical Hospital of University of São Paulo Medical School

• Grant number: 13/17477-4
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): December 01, 2013
• Effective date (End): November 30, 2014
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal researcher: Ana Cristina Aoun Tannuri
• Grantee: Nathassia Mancebo Avila de Rezende
• Home Institution: Instituto da Criança Professor Doutor Pedro de Alcantara (ICR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

INTRODUCTION: Acute liver failure (ALF) is a rare condition among children, and is followed by high mortality rates. When medical therapy is ineffective, liver transplantation (LT) is considered, which can be from a deceased or living donor. An aggressive and fast treatment is vital for patient's survival, considering the great number of complications related to this condition.OBJECTIVES: To find the relation between ALF cases characteristics, donors data and data related to the LT itself with the evolution, searching for ways of predicting patients' outcome.MATERIAL AND METHODS: We will perform a descriptive, retrospective and comparative study, based in the revision of medical records from children bearing ALF, admitted and treated at the Child Institute of the Clinical Hospital of FMUSP, from July 1989 to May 2013. The following data will be statistically analyzed: personal data, medical history, factors related to LF (cause, time since diagnosis), signs, symptoms and exams of the patient over time in which they were hospitalized (hemogram, hepatic enzymes, albumin, presence of encephalopathy, jaundice, renal failure), LT and postoperative factors (if reduced or whole graft, if deceased or living donor, priorization, waiting time, time of graft ischemia, biopsies, general complications, survival rates), in addition to donor data (BMI, ICU time, death cause).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AOUN TANNURI, ANA CRISTINA; PORTA, GILDA; MIURA, IRENE KAZUE; SANTOS, MARIA MERCES; RANGEL MOREIRA, DANIEL DE ALBUQUERQUE; AVILA DE REZENDE, NATHASSIA MANCEBO; MIYATANI, HELENA THIE; TANNURI, UENIS. Pediatric acute liver failure in Brazil: Is living donor liver transplantation the best choice for treatment?. LIVER TRANSPLANTATION, v. 22, n. 7, p. 1006-1013, JUL 2016. Web of Science Citations: 5.