| Grant number: | 18/24124-4 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | April 01, 2019 |
| End date: | March 31, 2020 |
| Field of knowledge: | Health Sciences - Medicine |
| Principal Investigator: | Fernanda Loureiro de Andrade Orsi |
| Grantee: | Júlia Ruete de Souza |
| Host Institution: | Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
Abstract Orthotropic liver transplantation (TOF) is one of the main therapeutic options for the terminal liver treatment of different etiologies, such as progression of complications, primary liver neoplasms, acute liver failure and metabolic diseases. Despite is healer, TOF may evolve due to complications such as acid-base and coagulopathy. Coagulopathy may lead to increased transfusion, which further compromises the prognosis of TOF. The association of acid-base with coagulopathy and transfusion is well studied in cases of severe polytrauma. However, this association is not anchored in TOF. The objective is to evaluate the association of metabolic acidosis with coagulation and transfusion disorders during the intraoperative period of TOF. The primary objective is to evaluate the association between values of excess blood base (BE) and fibrinogen values. The secondary objectives are to evaluate the association of BE, pH and lactate with activated partial thromboplastin time (aPTT), prothrombin time (PT), platelets and hemoglobin (Hb); as well as the association of BE, pH and lactate values with the total amount of blood components used during surgery. To do this we will carry out a cohort study, with a retrospective survey of diagnostic data, demographic data of the treatment, pre-transplantation exams, hepatic pre-reperfusion and hepatic post reperfusion and on complications of all patients undergoing liver transplantation at Hospital de Clinics of the University of Campinas (UNICAMP), from August 1, 2016 to January 1, 2018. To determine the association between acid-base disorders, coagulation and transfusional need, we will use linear regression models having the values of acid-base parameters as determinant variables and laboratory (coagulation) and clinical (transfusion) outcomes as dependent variables. | |
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