Biochemical markers related to lipid metabolism in adolescents with juvenile systemic lupus erythematosus (JSLE): relationship with cardiovascular risk

• Grant number: 13/21582-8
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): December 01, 2013
• Effective date (End): November 30, 2014
• Field of knowledge: Health Sciences - Medicine
• Principal researcher: Maria Teresa de Sande e Lemos Ramos Ascensão Terreri
• Grantee: Eugênia Jatene Bou Khazaal
• Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Juvenile systemic lupus erythematosus (JSLE) is a chronic, autoimmune, multi-systemic disease that affects individuals up to the age of 18, characterized by widespread inflammation of blood vessels and connective tissue, and production of autoantibodies, especially against nuclear antigens. Adult patients with SLE have high rates of morbidity and mortality from cardiovascular disease. In addition, they have some risk factors for developing chronic diseases that can compromise future survival of these individuals, such as high frequency of dyslipidemia, inadequate food consumption, increase of fat mass and lean mass reduction. The development of diagnosis and treatment of SLE in recent decades changed the morbidity and mortality of children and adolescents. Although the lethality of this disease has decreased, this group presents, in higher proportion, some complications such as dyslipidemia, osteoporosis and cardiovascular disease, that should be prevented. Therefore, once it is known that patients with SLE have a high cardiovascular risk, identifying changes on biochemical markers related to lipid metabolism and to endothelial inflammation and injury is very important, as it contributes to an early clinical approach to children and adolescents with SLE. (AU)