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Evaluation of the antiproliferative effects of perillyl alcohol in medulloblastoma cell lines

Grant number: 13/23881-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2014
Effective date (End): December 31, 2015
Field of knowledge:Biological Sciences - Genetics
Principal Investigator:María Sol Brassesco Annichini
Grantee:Marcela de Oliveira Silva
Home Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Medulloblastoma (MB) is a malignant brain tumor with high prevalence among children, (highest incidence 8 years old). Standard treatment consists of maximum surgical resection, followed by local and craniospinal radiotherapy and adjuvant chemotherapy. Children under 3 years of age, however, are more difficult to treat because the irradiation cannot be used due to the neurological damage associated with it. Thus, despite conventional treatments to improve survival rates, about one third of patients remain incurable with many of these treatments causing significant damage to long-term survivors. Perillyl alcohol (POH), a monoterpene found at low concentrations in various plants has shown beneficial effects for the treatment of various tumor types. Intranasal administration of POH is a practical and non-invasive strategy, which has shown usefulness in glioblastomas due to its ability to cross the blood-brain barrier, reaching the central nervous system, and reducing the systemic and side effects without significantly affecting normal cells. Nonetheless, the effects of this new treatment in MB are still unknown. Thus, the present project aims to analyze the in vitro effects of POH in MB cell lines on cell death, invasion and proliferation.