Aerobic exercise-induced mitochondrial adaptation: role of muscle mitophagy

• Grant number: 13/21065-3
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): January 01, 2014
• Effective date (End): September 30, 2017
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Patricia Chakur Brum
• Grantee: Paulo Roberto Jannig
• Home Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 14/26797-5 - Molecular mechanisms of aerobic exercise-induced mitophagy in skeletal muscle, BE.EP.DR

Abstract

The beneficial effects of aerobic exercise (AE) over disease prevention and treatment arise from acute and chronic adaptations in a variety of organic systems, which promotes resistance against homeostasis breakdown by metabolic perturbations. The increase in oxidative capacity induced by AE is considered the major factor for its health benefits. The skeletal muscle is one of the most important tissues required for exercise performance, with notable metabolic and structural adaptation capacity upon mechanical stimuli. Since skeletal muscles are rich in mitochondria and highly dependent on oxidative phosphorylation for energy production, it is not surprising the fact that AE-induced increases in aerobic capacity occurs mainly through mitochondrial adaptations. Nevertheless, the molecular mechanisms underlying AE-induced mitochondrial adaptation are far from been completely understood. Several studies have already demonstrated the AE capacity to induce mitochondrial biogenesis. Although the mitochondrial biogenesis is essential, the maintenance of the healthy ones through quality control mechanisms seems to be of equal or greater value to proper mitochondrial adaptation. This quality control occurs mainly by mitochondria fission and fusion, as well as by removal of damaged/aged mitochondria through autophagy (mitophagy). Even though it is already known that AE regulates mitochondrial fission and fusion, the role of mitophagy in AE-induced mitochondrial adaptations have never been studied. Therefore, we aim to study the role of mitophagy in the AE-induced skeletal muscle adaptations in rats. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JANNIG, PAULO R.; ALVES, CHRISTIANO R. R.; VOLTARELLI, VANESSA A.; BOZI, LUIZ H. M.; VIEIRA, JANAINA S.; BRUM, PATRICIA C.; BECHARA, LUIZ R. G. Effects of N-acetylcysteine on isolated skeletal muscle contractile properties after an acute bout of aerobic exercise. Life Sciences, v. 191, p. 46-51, DEC 15 2017. Web of Science Citations: 0.