Effect of Bradykinin on osteoclastogenesis in vitro

• Grant number: 13/20698-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2014
• End date: January 31, 2015
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Pedro Paulo Chaves de Souza
• Grantee: Letícia de Menezes Oliveira
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Besides the classical action of the kallikrein-kinin system (KKS) in the modulation ofthe vascular tonus, this system is also involved in different pathologies, some of thembeing inflammatory in nature. Inflammatory processes in the vicinity of the skeletongenerally leads to bone loss, and in vitro models demonstrate that kinins mayparticipate of inflammatory bone resorption by activating the B1 and B2 kininreceptors on osteoblasts leading to RANKL up-regulation. In contrast with thesefindings, some in vivo studies demonstrate an inhibitory role of the KKS on boneresorption and osteoclast differentiation. Since several drugs having the KKS as targetare available at the market, the knowledge about the mechanisms underlying the roleof kinins on bone resorption is very important to predict side effects and develop newdrugs. It is not known already if the kinins have a direct effect on osteoclasts.Therefore, the aim of the present project is to analyze the role of kinins onosteoclastogenesis in vitro.