| Grant number: | 13/13631-9 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | January 01, 2014 |
| End date: | June 30, 2014 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal Investigator: | Valéria Sutti Nunes |
| Grantee: | Eliton Juniro da Silva |
| Host Institution: | Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract The physiological oxidation of cholesterol results in oxysterols, which are transported by lipoproteins in the bloodstream to the liver where they act as a precursor of bile acids synthesis. Bile acids are secreted in the bile and feces. This transportation mechanism is inherent to the reverse cholesterol transport system where HDL-C plays an important role removing intracellular cholesterol and oxysterols from extrahepatic tissues. Cholesteryl ester transfer protein (CETP) redistributes oxysterols among all lipoproteins. Also, CETP activity and concentration are related to HDL-C concentration. Babiker & Diczfalusy have shown in healthy volunteers that 24-hydroxycholesterol (24-OHC) and 27-hydroxycholesterol (27-OHC) are higher in HDL-C fraction. Our previous study indicated that 27-OHC is higher in subjects presenting low HDL-C plasma concentrations. Hence, the aim of this study is to measure, by GC/MS method, the 24-; 25-; and 27-OHC concentrations in the lipoprotein fractions obtained by sequential ultracentrifugation (VLDL, LDL, HDL, lipid free fraction) in high and low HDL-C concentration checking if the distribution of 24-, 25- e 27-HDC among lipoproteins differs according to the HDL-C concentration. | |
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