Role of baroreflex in the time course of autonomic and metabolic alterations of fructose-overload hypertension

• Grant number: 13/23418-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: February 01, 2014
• End date: January 31, 2016
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Maria Claudia Costa Irigoyen
• Grantee: Fernando dos Santos
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

The increase of fructose consumption in recent decades is closely associated with a higher incidence of comorbidities such as obesity, dysautonomia and development of metabolic syndrome. However, the literature does not have an accurate characterization of events occurring during the development of these comorbidities. Base on these information, this paper aims to assess temporal changes in autonomic and metabolic parameters in a model of metabolic syndrome induced by fructose overload, with focus on the role of baroreflex, as evaluated by sinoaortic denervation. We used four experimental groups of animals (rats), followed by 90 days: control (C), denervated control (D), treated with fructose (F) and denervated treated with fructose (DF). The treated groups were submitted to a fructose overload (10%) in drinking water. The evaluation of the cardiovascular and autonomic parameters occurred by recording blood pressure and heart rate via telemetry once a week, 24 hours per day for 13 weeks. The monitoring of metabolic indices started with measurement of food and water consumption, body weight quantification and daily caloric intake, in addition blood glucose tests and insulin tolerance test were performed. Moreover, the animals were allocated in metabolic cage (24 hours each month of the protocol) to measure the urine volume. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTOS, FERNANDO; MOREIRA, EDSON DIAS; DE ANGELIS, KATIA; IRIGOYEN, MARIA CLAUDIA. Fructose Induces Metabolic Syndrome Associated with a Marked Inflammatory State. FASEB JOURNAL, v. 31, p. 1-pg., 2017-04-01. (13/23418-0)

DOS SANTOS, FERNANDO; MORAES-SILVA, IVANA C.; MOREIRA, EDSON D.; IRIGOYEN, MARIA-CLAUDIA. The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations. SCIENTIFIC REPORTS, v. 8, JUL 20 2018. (13/23418-0, 11/04111-6)

SANTOS, FERNANDO; DIPP, THIAGO; AGORD SCHAAN, BEATRIZ D.; CASALI, KARINA RABELLO; MORRIS, MARIANA; SIGNORI, LUIS ULISSES; MEA PLENTZ, RODRIGO DELLA; IRIGOYEN, MARIA CLAUDIA. Acute fructose overload induces baroreflex dysfunction in close relatives of type 2 diabetics. FASEB JOURNAL, v. 30, p. 2-pg., 2016-04-01. (13/23418-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SANTOS, Fernando dos. Temporal development of autonomic and metabolic alterations of hypertension by fructose overload. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.