Advanced search
Start date

The influence of chronic aerobic training and physical detraining on adiposity in subcutaneous and retroperitoneal rat fat PAD: characterization of apoptosis and adipogenesis

Grant number: 13/13601-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2014
Effective date (End): August 31, 2017
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Fabio Bessa Lima
Grantee:Rogério Antônio Laurato Sertié
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):16/14297-3 - The influence of cardiac natriuretic peptides on the browning of adipose tissue, BE.EP.PD


Obesity is considered a public health problem that affects all societies worldwide. Excessive white adipose tissue (WAT) is positively correlated with increased morbidity and mortality, mainly by increasing risk factors for cardiovascular and metabolic diseases. The physical exercise, a lifestyle habit, is both an important non-pharmacological tool to fight obesity and an interesting model system for studying the cellular and metabolic adaptations in WAT. However, most studies have focused on the exercise-induced metabolic adaptations in WAT, but there are few studies in the literature which attempt to analyze the influence of physical detraining on these adaptations; and, the cellular adaptations that occur in this tissue during training and detraining have been studied even less. Therefore, the present study aims to analyze the influence of training-detraining on adiposity in subcutaneous and retroperitoneal (visceral) fat depots, with a particular interest in the cell turnover in these fat cushions. For this purpose, we intend to analyze the adipogenesis and apoptosis processes, both at the cellular and molecular level (gene and protein expression), and to study lipolysis and lipogenesis. We hope to understand more about the effects of exercise on adiposity in WAT and the effects of its interruption.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SERTIE, ROGERIO A. L.; CURI, RUI; OLIVEIRA, ARICLECIO C.; ANDREOTTI, SANDRA; CAMINHOTTO, RENNAN O.; DE LIMA, THAIS MARTINS; PROENCA, ANDRE R. G.; REIS, GABRIELA B.; LIMA, FABIO B. The mechanisms involved in the increased adiposity induced by interruption of regular physical exercise practice. Life Sciences, v. 222, p. 103-111, APR 1 2019. Web of Science Citations: 1.
CAMINHOTTO, RENNAN DE OLIVEIRA; TAVARES DA FONSECA, FELIPE LUCAS; DE CASTRO, NATALIE CAROLINA; ARANTES, JOAO PEDRO; LAURATO SERTIE, ROGERIO ANTONIO. Atkins diet program rapidly decreases atherogenic index of plasma in trained adapted overweight men. Arquivos Brasileiros de Endocrinologia e Metabologia, v. 59, n. 6, p. 568-571, DEC 2015. Web of Science Citations: 7.
RENNAN DE OLIVEIRA CAMINHOTTO; FELIPE LUCAS TAVARES DA FONSECA; NATALIE CAROLINA DE CASTRO; JOÃO PEDRO ARANTES; ROGÉRIO ANTONIO LAURATO SERTIÉ. Atkins diet program rapidly decreases atherogenic index of plasma in trained adapted overweight men. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 59, n. 6, p. 568-571, Dez. 2015.

Please report errors in scientific publications list by writing to: