Estrogen and strength training influence on skeletal muscle morphology and oxidative stress of senile rats

• Grant number: 13/18907-2
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2014
• End date: August 31, 2016
• Field of knowledge: Biological Sciences - Physiology
• Principal Investigator: Rita Cássia Menegati Dornelles
• Grantee: Samuel Rodrigues Lourenço de Morais
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil
• Associated scholarship(s): 15/14592-2 - Estrogen and strength training relationship upon IGF-1, PGC-1±4 pathways, miRNAs and sirtuins on skeletal muscle of senile female rats, BE.EP.DR

Abstract

Parallel to aging, various physiological systems suffer decline in their functions. The decrease in plasma levels of sex steroids, characteristic of this population, strongly influences the composition of skeletal muscle tissue (SMT) and the functional performance. Therefore, it is necessary to develop preventive strategies aimed at mitigating the negative effects present during aging on the TME. The estrogen therapy (ET) has a protective effect on the maintenance of lean body mass and muscle strength in women, however, the literature is contradictory. Currently, the strength training (ST) is the most effective intervention in the prevention of TME integrity during senescence. However, the mechanisms involved on the beneficial effects induced by both strategies are not fully elucidated. Moreover, the literature shows controversial results when therapies are associated, in particular to the female senility. Therefore, it is necessary to understand the effects of THE, the practice of TF and the combination of both on skeletal muscle morphology and oxidative stress in women during senescence. Given the above, the objective of this study is to evaluate the influence of ET, TF and the association of muscle celss morphology (fiber type), muscle cross-sectional area (CSA), assessment of functional capacity, body weight and food intake, oxidative stress (SOD, CAT, GSH and DHE) and hormonal profile (E2, FSH,LH,P4 and DHEA) of senile rats.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LOURENCO MORAIS, SAMUEL RODRIGUES; GOYA, ALEXANDRE GINEI; URIAS, URSULA; JANNIG, PAULO ROBERTO; NOVA BACURAU, ALINE VILLA; MELLO, WAGNER GARCEZ; FALEIROS, PAULA LAZILHA; PENHA OLIVEIRA, SANDRA HELENA; GARCIA, VALDIR GOUVEIA; ERVOLINO, EDILSON; et al. Strength training prior to muscle injury potentiates low-level laser therapy (LLLT)-induced muscle regeneration. Lasers in Medical Science, v. 32, n. 2, p. 317-325, FEB 2017. (13/18907-2)

STRINGHETTA-GARCIA, CAMILA TAMI; LOURENCO MORAIS, SAMUEL RODRIGUES; FERNANDES, FERNANDA; PEREZ-UENO, MELISE JACON; ALMEIDA, RICARDO DE PAULA; QUIRINO LOUZADA, MARIO JEFFERSON; CHAVES-NETO, ANTONIO HERNANDES; ERVOLINO, EDILSON; MENEGATI DORNELLES, RITA CASSIA. Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats. SCIENTIFIC REPORTS, v. 7, OCT 31 2017. (13/18907-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MORAIS, Samuel Rodrigues Lourenço de. Influence of hormonal estrogenic therapy and strength training on skeletal muscle of senile rats. 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araçatuba Araçatuba.