Investigation of volatile organic compounds in sweat samples as biomarkers for cancer diagnosis

• Grant number: 13/19653-4
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: March 01, 2014
• End date: March 31, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Bruno Spinosa de Martinis
• Grantee: Fernanda Ferreira da Silva Souza Monedeiro
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 17/10387-0 - Study of volatile organic compounds as cancer biomarkers in urine samples employing SPME and GCxGC-TOF-MS analysis, BE.EP.DD

Abstract

Natural metabolic processes in the human organism leads to the formation of different volatile organic compounds, so that, in a pathological condition, different processes may occur in the cells, producing a different set of compounds. With respect to scientific research, internationally, volatile organic compounds, commonly known as VOCs, have been evaluated in biological samples in order to be associated with certain diseases, most currently with cancer, showing up as potential biomarkers of diseases. A promising trend for the study of these compounds is based on the selection of samples that can be obtained without subjecting the individual to invasive methods. This project is based on the need to develop an analytical methodology capable of analyzing VOCs in sweat samples from individuals with cancer, while being able to discern these from sweat samples of healthy individuals, in order to facilitate a rapid diagnostic method, not invasive, and that initially can complement the anatomic-pathologic, serum and imaging examinations. The sweat samples will be collected with appropriate adhesive device in patients with confirmed cancer and healthy volunteers (controls), and VOCs investigated through analysis employing gas chromatography coupled to mass spectrometry (GC / MS). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MONEDEIRO, FERNANDA; DOS REIS, RODOLFO BORGES; PERIA, FERNANDA MARIS; GOMES SARES, CLAUDIA TARCILA; DE MARTINIS, BRUNO SPINOSA. Investigation of sweat VOC profiles in assessment of cancer biomarkers using HS-GC-MS. JOURNAL OF BREATH RESEARCH, v. 14, n. 2, APR 2020. (13/19653-4)

DE CAMPOS, EDUARDO GERALDO; DA COSTA, BRUNO RUIZ BRANDAO; DOS SANTOS, FABIANA SPINETI; MONEDEIRO, FERNANDA; ALVES, MARCELA NOGUEIRA RABELO; SANTOS JUNIOR, WILSON JOSE RAMOS; DE MARTINIS, BRUNO SPINOSA. Alternative matrices in forensic toxicology: a critical review. Forensic Toxicology, AUG 2021. (17/18021-5, 17/10387-0, 13/19653-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MONEDEIRO, Fernanda Ferreira da Silva Souza. Investigation of volatile organic compounds in sweat samples as biomarkers in cancer diagnosis.. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (PCARP/BC) Ribeirão Preto.