| Grant number: | 11/17184-1 |
| Support Opportunities: | Regular Research Grants |
| Start date: | March 01, 2012 |
| End date: | February 28, 2014 |
| Field of knowledge: | Engineering - Electrical Engineering - Electrical Materials |
| Principal Investigator: | Ely Antonio Tadeu Dirani |
| Grantee: | Ely Antonio Tadeu Dirani |
| Host Institution: | Faculdade de Ciências Exatas e Tecnologia. Pontifícia Universidade Católica de São Paulo (PUC-SP). São Paulo , SP, Brazil |
| City of the host institution: | São Paulo |
| Associated researchers: | Ana Lúcia Manrique ; Annie France Frère Slaets ; Fernando Josepetti Fonseca ; Leonardo Giordano Paterno ; Luiz Carlos de Campos ; Mauro Francisco Pinheiro da Silva |
Abstract
This project proposes the study and development of a multisensory system (MS) for the non-invasive detection of chemical species, both at liquid and gaseous phases, related to diabetes, lung cancer, tuberculosis, and so on. Sick subjects exhale chemicals through breath and sweat which are related to particular metabolic process of a certain type of disease. Such chemicals could be precisely detected and quantified but the lack of an appropriate instrumentation such chemicals are not considered during the patient evaluation. Therefore, a biomedical instrumentation capable of performing this task should contribute to accomplish rapid and reliable diagnosis of diseases in sub-clinic level. The proposed MS offers distinguished features including low cost, operation at room temperature and a hybrid configuration of sensors (non-specific and specific sensors) interrogated under AC stimulus which imparts higher sensitivity and greater analytes discrimination capabilities. Non-specific sensors will be based on nanostructured films of semiconducting polymers, phthalocyanines, carbon nanotubes and inorganic nanoparticles whereas specific sensors will be produced by molecular imprinting techniques within polymeric and inorganic films. In this project, the electrical response of the MS, in vitro, in AC regime will be registered in the presence of acetone, alkanes (butane, hexane and 2-methylhexane) and 1-methylnaphthalene which are recognized as biomarkers of diabetes, lung cancer and lung tuberculosis, respectively. The responses will be further processed by multivariate data analysis tools. The detection properties, namely sensitivity, selectivity, detection limit and reset time will be investigated as a function of temperature and relative humidity. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant: |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |