Study and development of chemical sensors for non-invasive diseases diagnosis in human beings

• Grant number: 11/17184-1
• Support Opportunities: Regular Research Grants
• Duration: March 01, 2012 - February 28, 2014
• Field of knowledge: Engineering - Electrical Engineering - Electrical Materials
• Principal Investigator: Ely Antonio Tadeu Dirani
• Grantee: Ely Antonio Tadeu Dirani
• Host Institution: Faculdade de Ciências Exatas e Tecnologia. Pontifícia Universidade Católica de São Paulo (PUC-SP). São Paulo , SP, Brazil
• Associated researchers: Ana Lúcia Manrique ; Annie France Frère Slaets ; Fernando Josepetti Fonseca ; Leonardo Giordano Paterno ; Luiz Carlos de Campos ; Mauro Francisco Pinheiro da Silva

Abstract

This project proposes the study and development of a multisensory system (MS) for the non-invasive detection of chemical species, both at liquid and gaseous phases, related to diabetes, lung cancer, tuberculosis, and so on. Sick subjects exhale chemicals through breath and sweat which are related to particular metabolic process of a certain type of disease. Such chemicals could be precisely detected and quantified but the lack of an appropriate instrumentation such chemicals are not considered during the patient evaluation. Therefore, a biomedical instrumentation capable of performing this task should contribute to accomplish rapid and reliable diagnosis of diseases in sub-clinic level. The proposed MS offers distinguished features including low cost, operation at room temperature and a hybrid configuration of sensors (non-specific and specific sensors) interrogated under AC stimulus which imparts higher sensitivity and greater analytes discrimination capabilities. Non-specific sensors will be based on nanostructured films of semiconducting polymers, phthalocyanines, carbon nanotubes and inorganic nanoparticles whereas specific sensors will be produced by molecular imprinting techniques within polymeric and inorganic films. In this project, the electrical response of the MS, in vitro, in AC regime will be registered in the presence of acetone, alkanes (butane, hexane and 2-methylhexane) and 1-methylnaphthalene which are recognized as biomarkers of diabetes, lung cancer and lung tuberculosis, respectively. The responses will be further processed by multivariate data analysis tools. The detection properties, namely sensitivity, selectivity, detection limit and reset time will be investigated as a function of temperature and relative humidity. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAVALLARI, MARCO R.; IZQUIERDO, JOSE E. E.; BRAGA, GUILHERME S.; DIRANI, ELY A. T.; PEREIRA-DA-SILVA, MARCELO A.; RODRIGUEZ, ESTRELLA F. G.; FONSECA, FERNANDO J.. Enhanced Sensitivity of Gas Sensor Based on Poly(3-hexylthiophene) Thin-Film Transistors for Disease Diagnosis and Environment Monitoring. SENSORS, v. 15, n. 4, p. 9592-9609, APR 2015. (08/57706-4, 11/17184-1, 13/19420-0, 09/05589-7)

CAVALLARI, MARCO R.; BRAGA, GUILHERME S.; DA SILVA, MAURO F. P.; IZQUIERDO, JOSE E. E.; PATERNO, LEONARDO G.; DIRANI, ELY A. T.; KYMISSIS, IOANNIS; FONSECA, FERNANDO J.. A Hybrid Electronic Nose and Tongue for the Detection of Ketones: Improved Sensor Orthogonality Using Graphene Oxide-Based Detectors. IEEE SENSORS JOURNAL, v. 17, n. 7, p. 1971-1980, APR 1 2017. (15/08566-9, 13/19421-6, 13/19420-0, 11/17184-1, 09/05589-7, 08/57706-4)

PINHEIRO DA SILVA, MAURO FRANCISCO; DE OLIVEIRA, DEBORA ROSE; CAVALLARI, MARCO ROBERTO; TADEU DIRANI, ELY ANTONIO; TRIBONI, EDUARDO REZENDE; PATERNO, LEONARDO GIORDANO; FONSECA, FERNANDO JOSEPETTI; ANDO, ROMULO AUGUSTO; BAPTISTA, MAURICIO DA SILVA; LANDERS, RICHARD; et al. A simple visible light photo-assisted method for assembling and curing multilayer GO thin films. Materials Chemistry and Physics, v. 165, p. 125-133, SEP 1 2015. (11/17184-1, 15/06064-6, 13/19420-0)