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Rhamnolipids production by recombinant strain using agroindustrial waste as an alternative carbon source

Grant number: 14/00783-8
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): April 01, 2014
Effective date (End): August 31, 2016
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:José Gregório Cabrera Gomez
Grantee:Jhoanne Hansen
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):15/18871-3 - Heterologous production of rhamnolipid in recombinant strains of Pseudomonas putida KT2440, BE.EP.PD

Abstract

Surfactants are amphipathic molecules which accumulate in interphase, giving them theability to reduce the interfacial and surface tension of the medium. The nonpolar portionis often a hydrocarbon chain and the polar portion may be ionic (cationic or anionic),nonionic or amphoteric. Surfactants are among the most versatile molecules of theindustry, being used in the preparation of pharmaceutical and food products,decontamination of impacted environments and petroleum, agronomic and cosmeticindustries. However, petroleum-based surfactants have the disadvantage of highresistance to biodegradation and high toxicity when they accumulate in theenvironment. An alternative is the use of biological surfactants, known asbiosurfactants. However, its application is limited due to high cost of production whencompared to its similar chemical. Thus, research which aims to minimize the cost ofobtaining the biosurfactant are of great importance. This study aims to developstrategies for generation of rhamnolipid biosurfactant economically attractive, obtaininga recombinant microorganism with high production potential and using agroindustrialresidues as carbon source.