EEG-fMRI in refractory epilepsies: evaluation of its use in highly complex cases and comparison with invasive monitoring

• Grant number: 14/04266-8
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: September 15, 2014
• End date: February 28, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Fernando Cendes
• Grantee: Ana Carolina Coan
• Supervisor: Andreas Alexopoulos
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: Cleveland Clinic Foundation, United States
• Associated to the scholarship: 13/00099-7 - EEG-fMRI in the pre-operatory evaluation of patients with focal refractory epilepsies, BP.PD

Abstract

The use of invasive EEG monitoring is still necessary to the determination of the ictal onset zone (IOZ) in a significant number of patients with refractory epilepsies underwent pre-surgical evaluation. The development of techniques that allow the noninvasive determination of the IOZ may reduce the morbidity and costs involved in the preoperative evaluations of these individuals. The concomitant use of electroencephalogram associated with functional magnetic resonance imaging (EEG-fMRI) can reveal hemodynamic changes related to pathological neuronal ictal or inter-ictal activity, helping to determine the IOZ non-invasively. The aim of this study is to evaluate the contribution of EEG-fMRI in the preoperative evaluation of patients with refractory epilepsies who underwent invasive EEG recordings prior to the surgery. EEG-fMRI exams acquired in the Cleveland Clinic Epilepsy Center will be post-processed and analyzed. The interpretation of the will include: i) comparison of the concordance of inter-ictal related BOLD changes with the IOZ defined by invasive EEG in patients with refractory epilepsies; ii) comparison of the concordance of inter-ictal related BOLD changes with the area resected in the epilepsy surgery in patients seizure-free and non-seizure-free; iii) comparison of the patterns of inter-ictal related BOLD changes outside the area resected of patients seizure-free and non-seizure-free. With the results of this study, we expect to determine specific patterns of inter-ictal related BOLD changes that can be associated to a better surgical outcome in patients with refractory epilepsies and highly complex definition of the IOZ. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COAN, ANA CAROLINA; CAVALCANTE, CHARLINGTON M.; BURGESS, RICHARD C.. Utility of Functional MRI and Magnetoencephalography in the Diagnosis of Infantile Spasms and Hypsarrhythmia. JOURNAL OF CLINICAL NEUROPHYSIOLOGY, v. 39, n. 7, p. 8-pg., 2022-11-01. (14/04266-8)