Physical exercise and oxidative stress: influence of the training status in arterial hypertension and in the relationship between antioxidants and oxidants in elderly

• Grant number: 13/13146-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2014
• End date: June 30, 2015
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Hugo Celso Dutra de Souza
• Grantee: Andre Mourão Jacomini
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Systemic arterial hypertension is pointed as one of the major risk factors to heart failure, considered one of the greatest public health problems, especially for the elderly population. Oxidative stress, sedentary lifestyle and low levels of training status have been identified as a relevant etiological factors. Thus, the purpose of this study is: evaluate the oxidative stress through quantification of oxidants and antioxidants substances in hypertensive and normotensive elderly and verify if the level of training status contributes to modulate this relationship. These study will includ 200 elderly over 60 years old divided according to the level of training status which will be evaluated in two forms: indirect VO2max and a general functional fitness through the battery of tests for elderly by American Alliance for Health, Physical Education, Recreation and Dance (AAHPERD). Blood sample will be collected (12hs fasting) to the following analysis: glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, nitric oxide, catalase, superoxide dismutase and glutathione peroxidase. Body mass index (BMI), waist-hip ratio (WHR), and blood pressure will be evaluated for characteristics subject data. Values will be described as mean and standard deviation and Pearson correlation coefficient will be performed to verify possible relationships between variables and the analysis of variance (ANOVA) to detect possible differences between groups. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JACOMINI, ANDRE MOURAO; DUTRA DE SOUZA, HUGO CELSO; DIAS, DANIELLE DA SILVA; BRITO, JANAINA DE OLIVEIRA; PINHEIRO, LUCAS CEZAR; DA SILVA, ANDERSON BERNARDINO; DA SILVA, ROBERTA FERNANDA; TRAPE, ATILA ALEXANDRE; DE ANGELIS, KTIA; TANUS-SANTOS, JOSE EDUARDO; et al. Training Status as a Marker of the Relationship between Nitric Oxide, Oxidative Stress, and Blood Pressure in Older Adult Women. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016. (13/13146-3)

JACOMINI, ANDRE MOURAO; DUTRA DE SOUZA, HUGO CELSO; DIAS, DANIELLE DA SILVA; BRITO, JANAINA DE OLIVEIRA; PINHEIRO, LUCAS CEZAR; DA SILVA, ANDERSON BERNARDINO; DA SILVA, ROBERTA FERNANDA; TRAPE, ATILA ALEXANDRE; DE ANGELIS, KTIA; TANUS-SANTOS, JOSE EDUARDO; et al. Training Status as a Marker of the Relationship between Nitric Oxide, Oxidative Stress, and Blood Pressure in Older Adult Women. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2016, p. 9-pg., 2016-01-01. (13/13146-3)

JACOMINI, ANDRE M.; DIAS, DANIELLE DA SILVA; BRITO, JANAINA DE OLIVEIRA; DA SILVA, ROBERTA F.; MONTEIRO, HENRIQUE L.; LLESUY, SUSANA; DE ANGELIS, KATIA; AMARAL, SANDRA L.; ZAGO, ANDERSON S.. Influence of Estimated Training Status on Anti and Pro-Oxidant Activity, Nitrite Concentration, and Blood Pressure in Middle-Aged and Older Women. FRONTIERS IN PHYSIOLOGY, v. 8, MAR 7 2017. (13/13146-3, 15/24847-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

JACOMINI, Andre Mourão. Physical exercise and oxidative stress: influence of training status in arterial hypertension and in the relationship between antioxidants and oxidative substances in elderly.. 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.