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Relevance of thromboelastogram in predicting cardiovascular events after vascular surgery

Grant number: 13/27009-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2014
Effective date (End): December 31, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Daniela Calderaro
Grantee:Fernanda Augusto Justo
Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Previous studies have shown that high thrombogenicity in the perioperative period is related to cardiovascular complications. We have observed by impedance platelet aggregometry that patients resistant to acetylsalicylic acid have more thrombotic events after vascular surgery, without change in bleeding rate. However, this test does not consider coagulation as a global process, since it accounts for only one of its elements. The thromboelastogram (TEGR) is an exam that measures thrombogenesis assessing a broader picture of hemostasis, including initial hemodynamic stress, participation of platelets, coagulation system,thrombin generation and endogenous fibrinolysis. The present study aims to correlate the results from thromboelastograms of 174 patients who underwent vascular surgery using acetylsalicylic acid to post-operative cardiovascular and hemorrhagic outcomes. We are also evaluating the evolutionary behavior of the coagulation system comparing results from pre and post-operation, as well as the correlation between the parameters of the TEGR and the platelets aggregometry.

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