Modulation of natural killer cells on the differentiation and function of dendritic cells: study of the mechanisms involved and implications in cancer

• Grant number: 14/10290-9
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• Start date: August 29, 2014
• End date: August 28, 2015
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Jose Alexandre Marzagão Barbuto
• Grantee: Maria Alejandra Clavijo Salomón
• Supervisor: Giorgio Trinchieri
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: National Institutes of Health, Bethesda (NIH), United States
• Associated to the scholarship: 12/23478-0 - Effect of Natural Killer cells on the in vitro differentiation of monocytes into dendritic cells in cancer patients: study of the mechanisms involved, BP.DD

Abstract

Natural Killer (NK) cells although known for their cytotoxic capacity, have been studied in recent years, deeper and deeper in his role as modulators of the immune response. Dendritic cells (DCs) in turn, sentinels of the immune system and bridge between innate and adaptive immunity, has been widely studied in our laboratory and used as a therapeutic strategy in cancer patients. The role of the microbiota in the activation and function of the immune system in response to cancer has been explored and, nowadays, it is known that its lack can affect the function of DCs and chemotherapy or immunotherapy against cancer. However, the role of the microbiota on the modulatory role of NK cells has been unexplored. DCs differentiated from monocytes (Mo-DCs) derived from healthy donors, in the presence of NK cells, showed phenotypic and functional improvements while the phenotype and function of Mo-DCs differentiated in the presence of soluble factors secreted by NK cells are affected, suggesting that cells NK modulate the differentiation and function of Mo-DCs by different mechanisms, not yet explored. Therefore, the aim of this project is to investigate the mechanisms involved in the modulation exerted by NK cells on the differentiation and function of DCs, and to explore the role of microbiota in interactions between NK cells and DCs in the context of cancer. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CLAVIJO-SALOMON, MARIA A.; SALCEDO, ROSALBA; ROY, SOUMEN; DAS NEVES, RODRIGO X.; DZUTSEV, AMIRAN; SALES-CAMPOS, HELIOSWILTON; BORBELY, KAREN STEPONAVICIUS-CRUZ; SILLA, LUCIA; ORANGE, JORDAN S.; MACE, EMILY M.; et al. Human NK cells prime inflammatory DC precursors to induce Tc17 differentiation. BLOOD ADVANCES, v. 4, n. 16, p. 3990-4006, AUG 25 2020. (17/13686-9, 14/10290-9, 09/54599-5, 11/05331-0, 12/23478-0)