Evaluation of the antibacterial potential biosilicate® containing metals with biological action

• Grant number: 14/07483-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2014
• End date: July 31, 2015
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Carlos Henrique Gomes Martins
• Grantee: Patrícia Francieli Silva Alves
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

It is important to provide oral health dental restorative materials with antibacterial activity and thus prevent the harmful effects caused by oral bacteria. Therefore, numerous attempts to produce devices and dental restorative materials that exhibit antimicrobial activity have been conducted. A viable alternative has been the use of certain bioactive ceramics, as is the case Biosilicate®. Biosilicato® is a national ceramic high bioactivity and presenting appropriate properties to assist the processes of maintaining oral health. This study aims to evaluate the antibacterial activity against aerobic bacteria Biosilicate®, microaerophilic and anaerobic oral potentially pathogenic. Will be developed using the new formulations Biosilicate® containing metals with biological actions, presenting some advantages over the process originally established, especially with regard to industrial scale production. The antibacterial activity will be performed by the agar microdilution method for determination of Minimum Inhibitory Concentration (MIC), antibacterial tests will be the technique of direct contact and antibiofilm activity. The result of this project will enhance the studies contributing to the launch of new products on the market for use in dentistry and even in medicine. Thus the development of this project will promote a better quality of oral health of a large portion of the population.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SIQUEIRA, RENATO LUIZ; SILVA ALVES, PATRICIA FRANCIELI; MORAES, THAIS DA SILVA; CASEMIRO, LUCIANA ASSIRATI; DA SILVA, SIDNEY NICODEMOS; PEITL, OSCAR; GOMES MARTINS, CARLOS HENRIQUE; ZANOTTO, EDGAR DUTRA. Cation-doped bioactive ceramics: In vitro bioactivity and effect against bacteria of the oral cavity. CERAMICS INTERNATIONAL, v. 45, n. 7, A, p. 9231-9244, MAY 2019. (14/07483-0, 13/07793-6)

SIQUEIRA, RENATO LUIZ; SILVA ALVES, PATRICIA FRANCIELI; MORAES, THAIS DA SILVA; CASEMIRO, LUCIANA ASSIRATI; DA SILVA, SIDNEY NICODEMOS; PEITL, OSCAR; GOMES MARTINS, CARLOS HENRIQUE; ZANOTTO, EDGAR DUTRA. Cation-doped bioactive ceramics: In vitro bioactivity and effect against bacteria of the oral cavity. CERAMICS INTERNATIONAL, v. 45, n. 7, p. 14-pg., 2019-05-01. (13/07793-6, 14/07483-0)