Modulation of the autophagic process by high fat diet

• Grant number: 13/13480-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2014
• End date: July 31, 2017
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Mário Roberto Maróstica Junior
• Grantee: Carla Evelyn Coimbra Nuñez
• Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 15/23491-5 - Expression of autophagy genes in Ffar4 knockout mice., BE.EP.PD

Abstract

AbstractThe expansion of obesity and its associated comorbidities, as insulin resistance, has reached alarming levels and constitutes an emergent public health problem. The ingestion of fat rich diet leads to physiological and immune changes that determines adipose tissue hypertrophy and inflammation establishment. The qualitative change in which saturated fat acids are elevated and capable of activating the TLR4 receptors has been identified as the main factor that contributes to pro-inflammatory alterations associated with high fat diet. On the other hand, the unsaturated fatty acids É-3 are related to reduced inflammation. In this context, the autophagy emerges as an "immunologic paradigm" which is activated by a large array of immune sensors and contributes to the restriction as well as the amplification of the inflammatory signaling. Autophagy is positively stimulated by the TLR4 receptor. This receptor is activated by lipopolysaccharides from gram positive bacteria (LPS) as well as by free fatty acids and are directly linked to the inflammatory signal propagation in metabolic diseases. On the other side, the É-3 fatty acids are capable to block the TLR4 signaling. Thus, knowing how autophagy is modulated in response to different dietary fatty acid compositions could contribute not only to the understanding of the autophagic mechanism, but also to understand the relationship between fatty acids and metaiinflammation physiopatogenia. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BASEGGIO, ANDRESSA MARA; COIMBRA NUNEZ, CARLA EVELYN; VICENTE DRAGANO, NATHALIA ROMANELLI; LAMAS, CELINA ALMEIDA; DE CAMPOS BRAGA, PATRICIA APARECIDA; LENQUISTE, SABRINA ALVES; REYES REYES, FELIX GUILLERMO; ALVES CAGNON, VALERIA HELENA; MAROSTICA JUNIOR, MARIO ROBERTO. Jaboticaba peel extract decrease autophagy in white adipose tissue and prevents metabolic disorders in mice fed with a high-fat diet. PHARMANUTRITION, v. 6, n. 4, p. 10-pg., 2018-12-01. (13/13480-0, 15/20766-3, 15/50333-1)