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The wound healing process in FAT-1 mice: crosstalk between neurons and macrophages in the context of wounds

Grant number: 14/03500-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2014
Effective date (End): June 30, 2015
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal Investigator:Hosana Gomes Rodrigues
Grantee:Thamiris Candreva Robles
Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Associated research grant:13/06810-4 - Mechanisms of action of omega-3 and omega-6 in the tissue repair process: neuro-immune focus, AP.JP


Currently, it has been reported that the central nervous system ( CNS) has a fundamental role in inflammation by modulating the immune response. Inflammatory reflexes originated from infections or wounds, respond to sensory fibers of the vagus nerve, which in afferent fibers, travel to integrative regions of the brainstem. From these regions, the response is determined by the efferent pathways and modulates the immune system. The interaction of peripheral nerves of the skin and the immune system is mediated by cutaneous nerve fibers, which release neurotransmitters, which activate specific receptors in target cells of the skin, such as keratinocytes, fibroblasts, mast cells, Langerhans cells, endothelial cells, and immune cells infiltrated. These interactions influence on development, growth and cell differentiation, immunity, and recruitment of leukocytes. The resident macrophages are essential for maintaining tissue homeostasis by removing dead cells and produce growth factors, while in inflammation, recognize pathogens via specific pathogens receptors, inducing phagocytosis of these, interact with T cells, secrete cytokines and recruit other immune system cells. In this context, we intend to evaluate CNS involvement in inflammatory responses in FAT - 1 mice, which endogenously produce n-3 fatty acids from fatty acids n-6, in the context of the healing process. Our goal is to evaluate the influence of the nervous system on the healing process and on functions of macrophages in C57/Black 6 and FAT - 1 mouse. In studies of macrophage culture in the presence and absence of neurotransmitters, evaluate some cellular responses, such as the production of cytokines, eicosanoids, and reactive oxygen species. Evaluate the effects of the presence of n-3 fatty acids in the function of neurons, such as the production of neurotransmitters and cytokines. And finally, we investigate the crosstalk between neurons and macrophages isolated from control animals and FAT - 1. These trials will study the influence of neurons in some functions of macrophages, production of cytokines, and reactive oxygen species. (AU)

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