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In vitro biocompatibility evaluation of natural rubber/leather sheet to be used in textile industrials applications

Grant number: 13/24884-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2014
Effective date (End): August 31, 2017
Field of knowledge:Biological Sciences - Genetics - Mutagenesis
Principal Investigator:Aldo Eloizo Job
Grantee:Dalita Gomes Silva Morais Cavalcante
Home Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

The Department of Physics, Chemistry and Biology, Faculty of Sciences and Technology, University of State of Sao Paulo (UNESP - Presidente Prudente/SP/Brazil) developed a composite from the mixture of leather waste with natural rubber, which is already filed for patent. One possible application is the incorporation of this new material in products for the textile and footwear industries. However, as the composition of the leather waste has chromium, the question arises as to the biocompatibility of this new material and safe use for humans. Thus, the aim of this study is to conduct a study regarding the presence of chromium in this new material, defining the amount of chromium present as chromium found (trivalent and hexavalent) and evaluate the possible cytotoxic and genotoxic effects of the new composite, using as system - test two human cell lines. As results, expected - to meet the predominance of trivalent chromium in the structure of the composite and also that this does not have cytotoxic and genotoxic effects on the evaluated systems - tests. If the expected results are confirmed, it will be possible to apply this new composite to be used in the manufacture for the textile industry, which is always looking for new materials that meet the demands of a highly competitive market. It will also contribute to environmental quality and sustainable development, as it is creating the possibility of taking advantage of the leather waste, which is a major environmental problem.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, NATALIA M.; GOMES, ANDRESSA S.; CAVALCANTE, DALITA G. S. M.; SANTOS, LUIS F.; TEIXEIRA, SILVIO R.; CABRERA, FLAVIO C.; JOB, ALDO ELOIZO. Green synthesis of colloidal gold nanoparticles using latex from Hevea brasiliensis and evaluation of their in vitro cytotoxicity and genotoxicity. IET Nanobiotechnology, v. 13, n. 3, p. 307-315, MAY 2019. Web of Science Citations: 1.
CAVALCANTE, DALITA G. S. M.; GOMES, ANDRESSA S.; DOS REIS, ELTON A. P.; DANNA, CAROLINE S.; KERCHE-SILVA, LEANDRA E.; YOSHIHARA, EIDI; JOB, ALDO E. In vitro cytotoxicity and genotoxicity of composite mixtures of natural rubber and leather residues used for textile applications. TOXICOLOGY AND INDUSTRIAL HEALTH, v. 33, n. 6, p. 478-486, JUN 2017. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.