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Identification and characterization of bovine transcription factor repertoire

Grant number: 14/15183-6
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): October 01, 2014
Effective date (End): February 10, 2015
Field of knowledge:Biological Sciences - Genetics - Animal Genetics
Principal Investigator:Luciana Correia de Almeida Regitano
Grantee:Marcela Maria de Souza
Supervisor: Juan M. Vaquerizas
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Research place: Max Planck Society, Munster, Germany  
Associated to the scholarship:12/20328-8 - Allelic expression in genes associated with meat tenderness in Nellore by transcriptomic analysis, BP.DR


In order to increase the Brazilian competitiveness in international beef trade, molecular genetic studies have been focused on quality traits such as meat tenderness. The knowledge of the genetic contribution in the total variation of the traits can help in early prediction of the animal genetics potential and this, together with the classical tools for genetic breeding, can maximize the response to selection process. Although, to define the real contribution of DNA sequence differences in phenotypic diversity is necessary to understand the mechanisms that regulate gene expression, considering that this variation may also result in phenotypic variation between individuals. To identify one possible mechanisms that are affecting gene expression variation, the present project aims to build a bovine transcription factor (TF) repertoire to, afterwards, identify those related genes expressed in Nelore muscle tissue. This study will contribute for the main project and for further investigations since TF are important regulators of gene expression, controlling many biological processes and no previous bovine TF repertoire was described until this moment. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, MARCELA M.; ZERLOTINI, ADHEMAR; GEISTLINGER, LUDWIG; TIZIOTO, POLYANA C.; TAYLOR, JEREMY F.; ROCHA, MARINA I. P.; DINIZ, WELLISON J. S.; COUTINHO, LUIZ L.; REGITANO, LUCIANA C. A.. A comprehensive manually-curated compendium of bovine transcription factors. SCIENTIFIC REPORTS, v. 8, . (12/23638-8, 12/20328-8, 14/15183-6)

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