Preparation of solid-stabilized heteroarilzinc salts for application in functionalized heterocyclic compounds synthesis

• Grant number: 14/13869-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): August 01, 2014
• Effective date (End): July 31, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Giuliano Cesar Clososki
• Grantee: Bárbara Soares da Silva Rossato
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The main objective of this project is to synthesize solid-stabilized heteroarylzinc reagents to be used in Negishi cross-coupling reaction with various heteroaromatic halides under microwave irradiation. Furthermore, the application of these reagents in microwave-assisted carbonyl addition reactions will be also investigated.