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Leishmania chagasi infection in free-ranging wild mammals in a region of native forest, in the municipality of Campinas, São Paulo

Grant number: 14/13049-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): September 01, 2014
Effective date (End): February 29, 2016
Field of knowledge:Health Sciences - Collective Health - Epidemiology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Maria Rita Donalisio Cordeiro
Grantee:Lais Moraes Paiz
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Leishmaniasis is a zoonotic disease transmitted by sandflies of the subfamily Phlebotominae, whose etiologic agent is the protozoan Leishmania spp. A clear process of urbanization of visceral leishmaniasis has been observed, although this is primarily wild and man is an accidental host. The city of Campinas, State of São Paulo has epidemiological situation of municipality with canine transmission since 2009. In this year, it was registered the first autochthonous case of canine visceral leishmaniasis in a condominium located in the Environmental Protection Area (APA), highlighting the need for epidemiological research and surveillance actions. This study aims to assess the presence of Leishmania chagasi infections in free-ranging wild mammals from the APA of Campinas, through capture and blood collection every two months, for one year. Seroepidemiological survey will be carried out by assessing and quantifying anti-Leishmania spp. antibodies, using the Direct Agglutination Test (DAT) and Fast Immunoassay (Kalazar-detect"), and DNA detection of Leishmania spp., and L. chagasi by the technique of Polymerase Chain Reaction (PCR). Thus, we aimed to obtain information as to infection by L. chagasi in mammals from the APA of Campinas and the possible occurrence of a sylvatic cycle of AVL in the region. We expect to achieve results that contribute to the elucidation of the exact mechanisms of transmission and the introduction of the disease in the region. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PAIZ, LAIS MORAES; MOTOIE, GABRIELA; RICHINI-PEREIRA, VIRGINIA BODELAO; LANGONI, HELIO; MENOZZI, BENEDITO DONIZETE; TOLEZANO, JOSE EDUARDO; DONALISIO, MARIA RITA. Antibodies and Molecular Detection of Leishmania (Leishmania) infantum in Samples of Free-Ranging Marmosets (Primates: Callitrichidae: Callithrix spp.) in an Area of Canine Visceral Leishmaniasis in Southeastern Brazil. VECTOR-BORNE AND ZOONOTIC DISEASES, v. 19, n. 4, . (14/13049-0, 14/27212-0, 16/02572-0)
PAIZ, LAIS MORAES; DONALISIO, MARIA RITA; RICHINI-PEREIRA, VIRGINIA BODELAO; MOTOIE, GABRIELA; CASTAGNA, CLAUDIO LUIZ; TOLEZANO, JOSE EDUARDO. Infection by Leishmania spp. in Free-Ranging Opossums (Didelphis albiventris) in an Environmentally Protected Area Inhabited by Humans in Southeastern Brazil. VECTOR-BORNE AND ZOONOTIC DISEASES, v. 16, n. 11, p. 728-730, . (14/13049-0, 12/51267-4, 14/27212-0, 16/02572-0)
DONALISIO, MARIA RITA; PAIZ, LAIS MORAES; DA SILVA, VANESSA GUSMON; RICHINI-PEREIRA, VIRGINIA BODELAO; BRUNO VON ZUBEN, ANDREA PAULA; CASTAGNA, CLAUDIO LUIZ; MOTOIE, GABRIELA; HIRAMOTO, ROBERTO MITSUYOSHI; TOLEZANO, JOSE EDUARDO. Visceral leishmaniasis in an environmentally protected area in southeastern Brazil: Epidemiological and laboratory cross-sectional investigation of phlebotomine fauna, wild hosts and canine cases. PLoS Neglected Tropical Diseases, v. 11, n. 7, . (16/02572-0, 12/51267-4, 14/13049-0, 14/27212-0)

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