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Effect of different fatty acids maternal intake during pregnancy and lactation on epigenetic modifications and pro-inflammatory status of the fetus and 21-D-OLD offspring

Grant number: 14/10683-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2014
Effective date (End): May 31, 2019
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Luciana Pellegrini Pisani
Grantee:Laís Vales Mennitti
Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
Associated scholarship(s):17/16637-9 - The role of miRNAs in the programming of offspring fatty liver by maternal diet-induced obesity, BE.EP.DR


Maternal intake of different dietary fatty acids during pregnancy and lactation seems to modify the fetal "programming", epigenetic pattern and individual phenotype, influencing in the offspring susceptibility to the development of metabolic diseases. Therefore, the aim of the present study is to evaluate the epigenetic modifications and pro-inflammatory status of fetus and 21-d-old offspring from dams fed with different dietary fatty acids during pregnancy and lactation. In male fetus and 21-d-old offspring, we will assess: body weight, length and liver relative weight; placental weight and fatty acids profile; serum concentrations of triacylglycerol, glucose, NEFA and LPS; triacylglycerol hepatic content; global DNA methylation in liver; gene and protein expression of proteins involved in epigenetic mechanisms: DNMT1, DNMT3a, DNMT3b and MeCP2 in liver; HDAC enzyme activity in the liver; gene expression of inflammation-associated receptors: TLR4, IL-6R, TNFR1 and ADIPOR2 in the liver; protein expression in liver of IR, IRS-1 and NF-ºB (p50 and p50 subunit) in phosphorylated forms and IL-6, TNF-± and IL-10 liver content. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MENNITTI, LAIS VALES; OYAMA, LILA MISSAE; SANTAMARINA, ALINE BOVETO; DA PENHA OLLER DO NASCIMENTO, CLAUDIA MARIA; PISANI, LUCIANA PELLEGRINI. Early exposure to distinct sources of lipids affects differently the development and hepatic inflammatory profiles of 21-day-old rat offspring. JOURNAL OF INFLAMMATION RESEARCH, v. 11, p. 11-23, . (14/10683-0)
MENNITTI, LAIS VALES; CARPENTER, ASHA A. M.; LOCHE, ELENA; PANTALEAO, LUCAS C.; FERNANDEZ-TWINN, DENISE S.; SCHOONEJANS, JOSCA M.; BLACKMORE, HEATHER L.; ASHMORE, THOMAS J.; PISANI, LUCIANA PELLEGRINI; TADROSS, JOHN A.; et al. ffects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offsprin. International Journal of Obesity, v. 46, n. 2, . (19/22635-4, 14/10683-0, 17/16637-9)
MENNITTI, LAIS VALES; OYAMA, LILA MISSAE; SANTAMARINA, ALINE BOVETO; DO NASCIMENTO, OLLER; PISANI, LUCIANA PELLEGRINI. Influence of maternal consumption of different types of fatty acids during pregnancy and lactation on lipid and glucose metabolism of the 21-day-old male offspring in rats. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, v. 135, p. 54-62, . (14/10683-0)

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