Efficacy of low level laser therapy in animals of NFkappa beta strain subjected to the acute arthritis condition

• Grant number: 14/16544-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2014
• End date: September 30, 2015
• Field of knowledge: Biological Sciences - Morphology - Anatomy
• Principal Investigator: João Paulo Mardegan Issa
• Grantee: Bianca Ferreira Trawitzki
• Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Acute arthritis is an inflammation that affects many joints. The main form of treatment is still in invasive and painful methods. The aim of this study is to evaluate the effect of Low level laser therapy (LLLT), a non-invasive treatment at different wavelengths and number of sessions. 48 transgenic mice will be used, NFkappa Beta strain, and zymosan A injection will be used for acute arthritis induction. Mice will be treated with LLLT in a single and double application on different wavelengths. After euthanasia, collection and fixation of the hindlimbs, the histological analysis will be performed aiming to identify the presence of inflammatory infiltrate and the structure of the articular surfaces at histological slides. Finally, the data will be submitted to statistical analysis.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TRAWITZKI, BIANCA F.; LILGE, LOTHAR; DE FIGUEIREDO, FELLIPE A. T.; MACEDOA, ANA PAULA; ISSA, JOAO PAULO M.. Low-intensity laser therapy efficacy evaluation in mice subjected to acute arthritis condition. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 174, p. 126-132, SEP 2017. (12/24264-4, 14/16544-2)