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Effects of exercise resistance articular cartilage in an experimental model of knee osteoarthritis induced by transection of the anterior cruciate ligament in rats

Grant number: 14/13705-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2014
Effective date (End): August 31, 2016
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Ana Claudia Muniz Renno
Grantee:Amanda Almeida Siqueira
Home Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil

Abstract

Osteoarthritis (OA) of the knee has been increasingly more common worldwide and exercise has been shown to be an effective therapeutic strategy for restoring physical function and improved quality of life for these patients. However, the mechanisms activated by this action remain uncertain. The objective of this study is to evaluate the effects of resistance exercise on the articular cartilage of the knee of rats subjected to an experimental model of osteoarthritis induced by section of the anterior cruciate ligament (ACLT). 30 Wistar rats, males, separated into 3 groups (n = 10) will be used: control (CG); osteoarthritic (GO); osteoarthritic and subjected to resistance exercise protocol (GOL). The training will begin four weeks after surgery and will consist of jumps in liquid at 32 ° C means: 4 sets of 10 jumps each, with intervals of 30 seconds between sets 3 days a week for 8 weeks, with loads ranging from 50 - 80% of the body weight of the animal. To evaluate and compare the effects of training morphological and morphometric analyzes of cartilage (cellularity, thickness, density of chondrocytes and proteoglycan content) and protein expression of IL-1² will be held. It is expected that the results of this project will bring significant contribution in elucidating the mechanisms of action triggered by resistance exercise, thus optimizing their use in the rehabilitation of degenerative disorders. (AU)