Effect of Insulin-like Growth Factor-I (IGF-I) on parasitism of mouse peritoneal macrophages by Leishmania (L.) infantum

• Grant number: 14/08340-8
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): October 01, 2014
• Effective date (End): September 30, 2016
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Hiro Goto
• Grantee: Ariane Farias Leal
• Host Institution: Instituto de Medicina Tropical de São Paulo (IMT). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

In leishmaniasis it is known that for the resistance and susceptibility to infection the cellular immune response is considered most important. However in the initial phase non-specific factors are considered fundamental in determining the course of the disease. Besides the complement system, macrophage reactive oxygen and reactive nitrogen species, neutrophils and eosinophils, other factors have being considered including the Insulin-like Growth Factor-I. Great interest on the study of IGF-I in immunity in leishmaniasis was originated from the works done by Prof. Dr. Hiro Goto where it was shown that extrinsic IGF-I favors the proliferation of Leishmania and progression of the parasite infection, with decreased production of nitric oxide and arginase activation of macrophages and the parasite. In the present project we will study the influence of IGF-I on the parasitism of BALB/c mouse peritoneal macrophages using Leishmania (Leishmania) infantum. Similar studies are in progress with Leishmania (L.) major and Leishmania (L.) amazonensis but knowing that there are considerable biological differences among different Leishmania species, we will develop the studies now with L. (L.) infantum. The results from this study will contribute to the understanding of the differences in the behavior of infections caused by different Leishmania species and of the pathogenesis of visceral leishmaniasis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

REIS, LUIZA C.; RAMOS-SANCHEZ, EDUARDO MILTON; ARAUJO, FERNANDA N.; LEAL, ARIANE F.; OZAKI, CHRISTIANE Y.; SEVILLANO, ORLANDO R.; USCATA, BERNARDINA A.; GOTO, HIRO. Pleiotropic Effect of Hormone Insulin-Like Growth Factor-I in Immune Response and Pathogenesis in Leishmaniases. JOURNAL OF IMMUNOLOGY RESEARCH, v. 2021, MAY 5 2021. (14/08340-8, 19/25393-1, 18/14398-0, 17/02959-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

LEAL, Ariane Farias. Influence of Insulin-like growth factor (IGF) -I on the parasitism of mice peritoneal macrophages by Leishmania (L.) infantum. 2017. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Medicina Tropical de São Paulo (IMT) São Paulo.