Synthesis and characterization of a new class of injectables, termosensitives and biodegradables hydrogels as substrate for cell differentiation

• Grant number: 14/12428-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: November 01, 2014
• End date: June 19, 2018
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Eliana Aparecida de Rezende Duek
• Grantee: Daniel Vinícius Mistura
• Host Institution: Faculdade de Engenharia Mecânica (FEM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 15/20933-7 - Spectroscopy, swelling and temperature kinetics of an injectable hydrogels based on lactones and acrylamides, BE.EP.DR

Abstract

Hydrogels have been widely studied, especially as injectable materials for applications as biomaterials. These hydrogels may possess thermosensitive features near body temperature (LCST - Lower Critical Solution Temperature - around 37oC), in addition to rapid gelation, which allows it use as carrier drugs, cells or cell growth factors as injections. The current challenge is to make these materials biodegradables and suitable the mechanical properties for their use. The aim of this study will be to synthesize hydrogels of poly(N-iropropylacrylamide) (PNIPAAm) from a new class of macromer consisting of 2-hydroxyethyl methacylate (HEMA), poly(L-co-D,L lactic acid) and trimethylene carbonate (PLDLA-co-TMC) in order to synthesized material with inherent characteristics such as biodegradability and mechanical properties compatible to required applications in the field of tissue engineering. In addition, another aim for the hydrogel will assess your role as substrate in the differentiation of bone marrow-derived mesenchymal stem cells of rabbits in cardiomyocytes, aiming future application in cardiac tissue engineering. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MISTURA, Daniel Vinícius. Synthesis and characterization of a new class of injectable, thermoresponsive and biodegradable hydrogels as cell substract for cell differentiation. 2018. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia Mecânica Campinas, SP.